نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه فیزیولوژی ورزشی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران
2 گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران
10.30473/eab.2023.67998.1909
چکیده
بیان مساله: کبد، عضو اصلی مسئول کنترل متابولیک و سم زدایی متابولیک است که به طور قابل‌توجهی به پاکسازی پلاکهای بتا آمیلوئید کمک می‌کند. اختلال عملکرد کبدی ممکن است خطر ابتلا به آلزایمر را افزایش دهد.
هدف: بررسی اثر یک دوره تمرین هوازی همراه با ویتامین C بر آنزیم‌های کبدی و ظرفیت آنتی‌اکسیدانی در موشهای صحرایی آلزایمری
مواد و روشها: مطالعه حاضر یک تحقیق تجربی و بنیادی با پس آزمون و گروه کنترل بود که روی 35 سر موش صحرایی نر نژاد اسپراگو-داولی بین 14 تا 16 ماه انجام شد. نمونهها، به طور تصادفی به 5 گروه (7 سر در هر گروه) شامل 1) آلزایمر، 2) سالم، 3) تمرین، 4) ویتامین C و 5) تمرین + ویتامین C تقسیم شدند. تمرین به مدت هشت هفته، سه جلسه در هفته تمرین هوازی بر نوار گردان پرداختند. پروتئین تام موجود در بافت کبد برای اندازه‌گیری TAC، MDA، سطوح آلانین آمینوترانسفراز (AST)، آلکانین فسفاتاز (AST) و آسپارتات آمینوترانسفراز (AST) مورد سنجش قرار گرفت.
یافتهها: مقادیر AST، ALT و ALP، MDA و TAC در گروه کنترل مبتلا به بیماری آلزایمر به طور معنیداری بیشتر از گروه کنترل سالم بود (05/0>P). پس از مداخله، AST، ALT و ALP در گروه‌های تمرین و مصرف مکمل ویتامیل C به طور معنی داری کمتر از گروه‌های عدم تمرین بود (001/0=P).
نتیجه‌گیری: تمرین هوازی و مکمل دهی ویتامین C در بهبود فاکتورهای کبدی در موشهای صحرایی مبتلا به آلزایمر موثر است. با اینحال، تاثیری بر میزان MDA و TAC ندارد.
کلیدواژه‌ها
موضوعات
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