نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه فیزیولوژی ورزشی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران
2 گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران
10.30473/eab.2026.76570.2020
چکیده
مقدمه: مطالعه حاضر با هدف تأثیر تمرین تناوبی شنا با شدت بالا و مکمل‌دهی رسوراترول بر محتوای پروتئین‌های JNK3 وFOXO3a در بافت مغز موش‌های صحرایی سالمند، صورت گرفت.
روش پژوهش: پژوهش حاضر از نوع تجربی- بنیادی بود که روی 40 سر موش صحرایی نژاد ویستار سالمند که از مرکز نگهداری حیوانات دانشگاه علوم پزشکی شیراز تهیه شده بودند، صورت گرفت. نمونه به‌طور تصادفی به پنج گروه کنترل (8 سر)، تمرین (8 سر)، مکمل (8 سر)، تمرین+ مکمل (8 سر) و محلول (8 سر) تقسیم شدند. تمرین HIIT شنا به‌مدت شش هفته (14 نوبت 20 ثانیه‌ای شنا با 10 ثانیه استراحت بین هر نوبت) و مکمل رسوراترول روزانه 10 میلی‌گرم به‌ازای هر کیلوگرم وزن بدن در گروه‌های مداخله، صورت گرفت.
یافتهها: یافتهها حاکی از وجود تفاوت معنی‌دار بین میانگین محتوای پروتئین‌های JNK3 و FOXO3a در گروه‌ها بود (0001/0P=). مقایسه دو به دو گروه‌ها نشان داد که محتوای پروتئین‌های JNK3 و FOXO3a بین جفت گروه‌های کنترل و مکمل، کنترل و تمرین، کنترل و تمرین+ مکمل، محلول و مکمل، محلول و تمرین، محلول و تمرین+ مکمل، مکمل و تمرین و همچنین مکمل و تمرین+ مکمل تفاوت معنیداری داشت (0/05>P). تفاوت معنیداری بین گروه تمرین و مکمل+ تمرین به لحاظ محتوای پروتئین‌های JNK3 (0/99<P) و FOXO3a (0/97=P) مشاهده نشد.
بحث و نتیجه‌گیری: تمرین شنای تناوبی با شدت بالا و مکمل‌دهی رسوراترول منجر به کاهش محتوای پروتئین‌های JNK3 و FOXO3a در بافت مغز موش‌های صحرایی می‌شود
کلیدواژه‌ها
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