Document Type : Article
Authors
1 Associate Professor, Department of Biology, Science and Research Branch, Islamic Azad University, Fars
2 MSc Student, Department of Biology, Science and Research Branch, Islamic Azad University, Fars
3 Assistant Professor, Stem Cell and Transgenic Technology Research Center, Ghadir Hospital, Shiraz University of Medical Sciences, Shiraz
4 PhD Graduate of Animal Physiology, Department of Biology, Science and Research Branch, Islamic Azad University, Fars
Abstract
Increasing the levels of blood lipids is the most common factors in diabetes that will exacerbate its complications. PJ (Pomegranate juice) is a nutrient with medical purposes. The present study was aimed to investigate the effects of pomegranate juice on levels of triglycerides, cholesterol; LDL and HDL in healthy and diabetic adult male rats were done. In the study, 90 adult male rats weighing 200-220 g were divided into groups of control, diabetic and non-diabetic experimental groups. Each group includes 9 mice. Experimental groups received respectively 1, 2 and 4 ml of pomegranate juice per rat for 21 days. To create diabetes by Intra-peritoneal injection, streptozotocin 60mg/kg was used. At the end of experiment the animal hearts, serum levels of triglycerides, cholesterol, LDL and HDL were measured. Data were analyzed by ANOVA and LSD tests. The results showed that pomegranate juice in doses of 2 and 4 ml caused a significant reduction in triglyceride levels, respectively, P<0. 05 and P<0. 001, cholesterol at doses of 1, 2 and 4 ml, respectively, (P<0. 05, P<0. 01 and P<0. 001), LDL at doses of 2 and 4 ml (P<0. 01) and increased serum HDL in 4 ml (P<0. 05) in the diabetic group compared to control group and non-diabetic groups had no significant effect. Pomegranate juice is probably having a flavonoid and minerals such as zinc and by increasing insulin levels caused to reduce the amount of triglycerides, cholesterol, LDL and increase HDL in diabetic rats.
)