In collaboration with Payame Noor University and Iranian Society of Physiology and Pharmacology

Document Type : Article

Authors

1 M. A., Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 Assistant Professor, Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran

3 Associate Professor, Department of Physiology, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract

Abstract
Anxiety is a common disease in the society. About 500 million people worldwide suffer from this disorder. 85% of people with depression also have anxiety. According to anxiolytic effects of different zinc chloride in male and female rats is Castration post- pubertaly, this was investigated, the effect of zinc chloride on anxiety and deppresive behaviors of rats, in gonadectomized peri-pubertaly. In this experiment, fifty male rats were gonadectomized at postnatal day 21-22 and at puberty were divided into Six groups, control, sham (saline), gonadectomized (saline) and the gonadectomized groups receiving Zinc chloride 5, 10 and 20 mg/kg. Then on postnatal day 75, different doses of zinc chloride (5, 10 and 20 mg/kg; IP) were administered 30 min before the elevated plus maze and forced swimming test. The results showed in gonadectomized group (saline) anxiety did not reach to a significant criterion. Zinc chloride (20 mg/kg) significantly increase the time spent in the open arms in gonadectomized (20 mg/kg) group compared to the gonadectomized group (p 

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References
 
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