Animal physiology
Seyed Ebrahim Hosseini; Elham Rezaei; Davood Mehrabani
Articles in Press, Accepted Manuscript, Available Online from 19 October 2014
Abstract
Increasing the levels of blood lipids is the most common factors in diabetes that will exacerbate its complications. PJ (Pomegranate juice) is a nutrient with medical purposes. The present study aimed to investigate the effects of pomegranate juice on levels of triglycerides, cholesterol; LDL and HDL ...
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Increasing the levels of blood lipids is the most common factors in diabetes that will exacerbate its complications. PJ (Pomegranate juice) is a nutrient with medical purposes. The present study aimed to investigate the effects of pomegranate juice on levels of triglycerides, cholesterol; LDL and HDL in healthy and diabetic adult male rats were done. In the study, 90 adult male rats weighing 220-200 g were divided into groups of control, diabetic and non-diabetic experimental groups. Each group includes 9 mice. Experimental groups received respectively 1, 2 and 4 ml of pomegranate juice per rat for 21 days. To create diabetes by Intra-peritoneal injection, streptozotocin 60mg/kg was used. At the end of experiment by the phlebotomizing the animal hearts, serum levels of triglycerides, cholesterol, LDL and HDL were measured. Data were analyzed by ANOVA and LSD tests. The results showed that pomegranate juice in doses of 2 and 4 ml caused a significant reduction in triglyceride levels, respectively, in the P
tahereh Nikkhah; Amir Arasteh
Abstract
Diabetes and liver diseases are serious problems and threaten the health of communities. Nettle has been introduced in traditional Iranian medicine as a blood glucose lowering drug. There are conflicting scientific reports about the effects of reducing the blood sugar of nettle, but this plant has good ...
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Diabetes and liver diseases are serious problems and threaten the health of communities. Nettle has been introduced in traditional Iranian medicine as a blood glucose lowering drug. There are conflicting scientific reports about the effects of reducing the blood sugar of nettle, but this plant has good antioxidant and anti-inflammatory properties to reduce liver damage. Current study, examines the anti-diabetic and liver protective effects of the aqueous extract of urtica dioica in vistar male rats. The mice were divided into five groups and in order to investigation of anti-diabetic and liver protective effects, test groups obtained daily 2.5 and 5 ml/kg of the aqueous extract of urtica dioica orally for 14 and 32 days, respectively. Blood glucose was measured with a glucometer and liver enzyme activity was measured with ParsAzmoon kits. The results were analyzed using Student's T–Test and ANOVA using SPSS software version 21. Blood sugar levels in first and second test groups (170 and 122 mg/dl) showed a significant decrease compared to the negative control group (446 mg/dl). The activity of liver enzymes in the first and second test groups also showed a significant decrease compared to the negative control group. The aqueous extract of urtica dioica has beneficial effects in managing diabetes and maintaining the health of liver cells against toxic compounds.
Zeynab Amanzadeh; Felor Zargari; Alireza Khalilaria
Abstract
Diabetes mellitus is a metabolic disorder that is created by hyperglycemia and impaired insulin secretion, resistance to insulin action or both. Researches show that aqueous extracts of white tea has an antioxidant properties but few studies have been conducted on the effects of diabetic and hyperlipidemic. ...
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Diabetes mellitus is a metabolic disorder that is created by hyperglycemia and impaired insulin secretion, resistance to insulin action or both. Researches show that aqueous extracts of white tea has an antioxidant properties but few studies have been conducted on the effects of diabetic and hyperlipidemic. The aim of this study was to evaluate the effect of aqueous extract of white tea on the lipid profile and blood glucose in streptozotocin-induced diabetic rats. In the experimental study, 32 male Wistar rats were randomly divided into 4 groups of 8 were; First group, control group that received standard diet and a daily 1ml of distilled water via gavage; the second group, streptozotocin-induced diabetic rats; the third group, healthy rats aqueous extract of white tea (1.5 percent) were consumed; the forth group, diabetic rats that were consumed aqueous extracts of white tea (1.5 percent). After the treatment period (30 days) to determine blood glucose levels and lipid profile was performed and the data were analyzed with SPSS software (P<0.05). A significant decreases in serum levels of glucose, LDL, cholesterol and triglyceride and significant increase in levels of HDL and weight were observed in the group receiving aqueous extract of white tea (P<0.05). The results showed that aqueous extracts of white tea decreases serum levels of glucose, triglycerides, total cholesterol, LDL and HDL cholesterol levels significantly (P<0.05). The aqueous extracts of white tea is effective for hyperglycemia and hyperlipidemia in diabetic rats.
Rahmatollah Parandin
Abstract
Recent reports have shown that some Plant Isoflavones have beneficial effects on diabetes and liver health in human and laboratory animals. The aim of this study was to administrate of hydroalcoholic extract of Trifolium pretense (red clover) as a plant rich in Isoflavones compounds and its effects on ...
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Recent reports have shown that some Plant Isoflavones have beneficial effects on diabetes and liver health in human and laboratory animals. The aim of this study was to administrate of hydroalcoholic extract of Trifolium pretense (red clover) as a plant rich in Isoflavones compounds and its effects on serum levels of glucose and liver enzymes (AST, ALT and ALP) in mice. In this experimental study, 42 male mice were divided into 6 groups of 7, including healthy control, diabetic without treatment (positive control), diabetic treated with glibenclamide groups, and three diabetic groups treated respectively with 250, 500 and 750 mg/kg of hydroalcoholic extract of red clover by gavage for 15 days. Diabetes was induced by intraperitoneal injection of streptozotocin, 60 mg/kg. On the last day, serum glucose and Liver Enzymes (ALT, ALP and AST) levels were measured. The data were analyzed by SPSS statistical software and OneWay ANOVA test. The significant was shown with (P<0.05).Doses of 500 mg/kg and 750 mg/kg of extract were significantly (P<0.001) decreased serum glucose compared with positive control group. Assessment of liver enzymes shown that AST level in 750mg/kg group (P<0.001), ALT level in 500 mg/kg (P<0.01) and 750 mg/kg (P<0.001) groups, and ALP level in 250 mg/kg (P<0.05), 500 mg/kg (P<0.001) and 750 mg/kg (P<0.001) groups significantly decreased compared with positive control group. It seems that the red clover has anti-diabetic and hepatoprotectiveeffects.
Yadolah Edalatpanah; Saied Rezaei Zarchi; Fariba Enayati Parvar; Susan Rostam Pour; Leila Moradi Jafari
Abstract
Abstract Diabetes mellitus is a common metabolic disorder, with complications caused by many health problems in society. Reducing blood glucose levels in diabetic patients with medicinal herbs is of great clinical importance. This study was performed to investigate the effects of Cedar Butanlite Extract ...
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Abstract Diabetes mellitus is a common metabolic disorder, with complications caused by many health problems in society. Reducing blood glucose levels in diabetic patients with medicinal herbs is of great clinical importance. This study was performed to investigate the effects of Cedar Butanlite Extract on insulin-induced hypoglycemia in Streptozotocin Wistar male diabetic rats. In this study, 40 Wistar rats with a weight range of 250-300 gr were selected and divided into 5 groups. Blood glucose levels were measured by glucose oxidase assay. Data were analyzed by SPSS-24 software and t-test. Charts were prepared using Excel software. The results showed that the mean glucose level of diabetic rats treated with insulin and alcoholic extract of cedar showed a significant decrease compared to insulin treatment and cedar treatment (P
Namdar Yousofvand; Vahid Hasanvand
Volume 7, Issue 1 , September 2018, , Pages 27-33
Abstract
Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and ...
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Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and food for 45 days and injected normal saline on 15th day. Control (diabetic by STZ at 40 mg/kg dose on 15th day) and the prevention group by garlic flower extract at a dose of 360 mg/Lit in drinking water received a treatment period for 15 days before diabetes. One dose of STZ 40mg/kg was injected intraperitoneally. The hematocrit of blood samples was measured, using the ABACUS-c Diatron device (Austria). Hematocrit showed a significant increase (p
Vahid Hasanvand; Namdar Yousofvand
Volume 6, Issue 4 , June 2018, , Pages 67-73
Abstract
Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water ...
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Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and food for 45 days and injected normal saline on 15th day. Control (diabetic by STZ at 40 mg/kg dose on 15th day) and the prevention group by garlic flower extract at a dose of 360 mg/Lit in drinking water received a treatment period for 15 days before diabetes. One dose of streptozotocin 40mg/kg was injected intraperitoneally. The hematocrit of blood samples was measured, using the ABACUS-c Diatron device (Austria). Hematocrit showed a significant increase (p
Fatemeh Nabiyouni; Gholamhasan Vaezi; Ali Akbar Malekirad; Mohammad Abdollahi
Volume 5, Issue 1 , September 2016, , Pages 31-38
Abstract
Diabetes is one of the most common metabolic diseases and in the long term affects many parts of body, including liver and kidneys. This study was to investigate alcoholic extract effect of Alhagi camelorum on functional tests of liver and kidney in diabetic rats induced by streptozotocin. In this study, ...
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Diabetes is one of the most common metabolic diseases and in the long term affects many parts of body, including liver and kidneys. This study was to investigate alcoholic extract effect of Alhagi camelorum on functional tests of liver and kidney in diabetic rats induced by streptozotocin. In this study, 28 Wistar male rats were divided into the four groups (n = 7): non-diabetic control group received normal diet, diabetic group was induced by streptozotocin and received 1ml of normal saline daily as extract solvent , two diabetic experimental groups received alcoholic extract of Alhagi Camelorum at dose of 200 mg/kg and 300 mg/kg by gavage, respectively. To induce diabetes, streptozotocin was injected to rats intraperitoneally at dose of 50 mg/kg. Blood samples were collected at day 21 from all groups and the related blood factors were measured and analyzed by SPSS (ANOVA). The findings show that there was a significant increase in creatinine, urea levels and liver enzymes in diabetic control group when compared to the non-diabetic control group. While the same amount factors show decrease in the groups receiving alcoholic extract of Alhagi Camerolum. The results show that alcoholic extract of aerial parts of Alhagi Camerolum causes to the decreased creatinine, urea levels and liver enzymes.
Farzam Sheikhzadeh Hesari; Nazli Khajehnasiri
Volume 5, Issue 1 , September 2016, , Pages 83-91
Abstract
A cardiovascular problem is one of the common complications of diabetes. Connexin is the predominant protein subunit in gap junction structure which is important in communication between cells. Considering the role of connexin, this question can be created in the mind whether changes in phosphorylated ...
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A cardiovascular problem is one of the common complications of diabetes. Connexin is the predominant protein subunit in gap junction structure which is important in communication between cells. Considering the role of connexin, this question can be created in the mind whether changes in phosphorylated connexin 43 occurs in diabetics thoracic aorta or not? 20 male Wistar rats (30050g) were randomly divided into two groups (n=10): control and diabetic group. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (60 mg/Kg). After 60-days, rats were anaesthetized and then thoracic aorta was isolated and immediately Freeze, at the end phosphorylated connexin 43 levels were measured by ELISA method. In this study, a significant increase in the level of connexin 43 is observed in the diabetic group (P
S. E. Hosseini; Elham Rezaei; Dawod Mehrabani; Farnaz Tavakoli
Volume 2, Issue 1 , March 2014, , Pages 13-20
Abstract
Increasing the levels of blood lipids is the most common factors in diabetes that will exacerbate its complications. PJ (Pomegranate juice) is a nutrient with medical purposes. The present study was aimed to investigate the effects of pomegranate juice on levels of triglycerides, cholesterol; LDL and ...
Read More
Increasing the levels of blood lipids is the most common factors in diabetes that will exacerbate its complications. PJ (Pomegranate juice) is a nutrient with medical purposes. The present study was aimed to investigate the effects of pomegranate juice on levels of triglycerides, cholesterol; LDL and HDL in healthy and diabetic adult male rats were done. In the study, 90 adult male rats weighing 200-220 g were divided into groups of control, diabetic and non-diabetic experimental groups. Each group includes 9 mice. Experimental groups received respectively 1, 2 and 4 ml of pomegranate juice per rat for 21 days. To create diabetes by Intra-peritoneal injection, streptozotocin 60mg/kg was used. At the end of experiment the animal hearts, serum levels of triglycerides, cholesterol, LDL and HDL were measured. Data were analyzed by ANOVA and LSD tests. The results showed that pomegranate juice in doses of 2 and 4 ml caused a significant reduction in triglyceride levels, respectively, P<0. 05 and P<0. 001, cholesterol at doses of 1, 2 and 4 ml, respectively, (P<0. 05, P<0. 01 and P<0. 001), LDL at doses of 2 and 4 ml (P<0. 01) and increased serum HDL in 4 ml (P<0. 05) in the diabetic group compared to control group and non-diabetic groups had no significant effect. Pomegranate juice is probably having a flavonoid and minerals such as zinc and by increasing insulin levels caused to reduce the amount of triglycerides, cholesterol, LDL and increase HDL in diabetic rats.
