Davoud Fazli; Aliakbar Malekirad
Abstract
Reactive oxygen species (ROS) are cytotoxic agents that lead to significant oxidative damage. Bisphenol A (BPA) is a contaminant toxic, oxidative and estrogenic effects. Purslane is a promising natural product, which could be useful for the prevention of chronic diseases caused by oxidative stress. In ...
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Reactive oxygen species (ROS) are cytotoxic agents that lead to significant oxidative damage. Bisphenol A (BPA) is a contaminant toxic, oxidative and estrogenic effects. Purslane is a promising natural product, which could be useful for the prevention of chronic diseases caused by oxidative stress. In this study 49 adult male rats (250 10g) were divided randomly in 7 groups (n=7): Control, Sham (500 ug corn oil\Kg BW), Toxin group (500ug BPA\kg BW), Positive control (100mg purslane hydroalcoholic extract\kg BW) and 3 purslane treated groups (500ug BPA + 50,100&150 mg purslane\kg BW). All injections are done by i.p rout in 14 consequently days. At the end of administration time (14 day) all animals were anesthetized with Chloral hydrate and sacrificed, then liver samples isolated to preparing tissue homogenates for measure antioxidant enzymes including SOD, CAT, TAC, GPX and MDA. Data are analyzed in SPSS statistical software by one way ANOVA with Tukey posttest. Analyzed data showed that MDA, TAC, CAT, GSH and GPX measures are modified in purslane treated groups compared to the bisphenol A group which indicates that the portulaca oleracea extract can improve the hepatotoxicity of bisphenol A induced.
Fisheries
Mojtaba Ghorbanpour delavar; Shayan Ghobadi; Saber Vatandoust; Hamed Manouchehri; Reza Changizi
Abstract
Metal oxide nanoparticles are one of the most widely used compounds among nanoparticles that have wide applications in various fields and thus increase their release into the environment and their potential impact on various organisms, especially aquatic organisms in the aquatic ecosystem. Nanoparticles ...
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Metal oxide nanoparticles are one of the most widely used compounds among nanoparticles that have wide applications in various fields and thus increase their release into the environment and their potential impact on various organisms, especially aquatic organisms in the aquatic ecosystem. Nanoparticles have high chemical and biological reactivity by increasing their surface to volume ratio, which leads to increased production of free radicals. The produced free radicals disrupt the oxidation and natural regeneration of the body's cells and cause oxidative damage in organisms and many diseases. The aim of this study was to investigate the oxidative effect of nickel nanoparticles in Carassius auratus that could open a new horizon in relation to the challenges in aquatic environments. The study groups include the control group and the treatment group with nickel nanoparticles. Each treatment with three replications each included 12 fish per replication. At the end of the period, liver samples were isolated and collected for oxidative damage. Total antioxidant levels, MDA, glutathione and the antioxidant enzymes catalase, glutathione S-transferase and superoxide dismutase were measured in all groups. The results showed that treatment with nickel oxide nanoparticles decreased the level of total anti oxidants and increased the level of MDA in the group treated with nickel oxide nanoparticles. These results showed strong evidence of inducted of cellular oxidative stress induced by exposure to nickel oxide nanoparticles. Also, by comparing the control treatments and the treatment of nickel oxide nanoparticles, it can be concluded that long-term exposure to nickel oxide nanoparticles can aggravate oxidative damage to fish liver tissue.
Fereshteh Keshavarzian; Abdolhassan Doulah; Maryam Rafieirad
Abstract
Parkinson is a chronic and widespread neurodegenerative disorder. In this study, the effects of swimming exercise and oleuropein supplementation on oxidative stress of brain tissue in experimental model of Parkinson's disease in rat were investigated. In this experimental study, 40 adult male Wistar ...
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Parkinson is a chronic and widespread neurodegenerative disorder. In this study, the effects of swimming exercise and oleuropein supplementation on oxidative stress of brain tissue in experimental model of Parkinson's disease in rat were investigated. In this experimental study, 40 adult male Wistar rats were selected and divided into five groups including: control group, Parkinson's group, swimming exercise, oleuropein consumption, swimming exercise with oleuropein consumption. The groups were forced to swim for 4 weeks (five sessions per week for 30 minutes each session) and groups 4 and 5 received 20 mg of oleuropein daily per kilogram of body weight orally for 4 weeks. Serum levels of the variables were evaluated using the thiobarbituric acid method. Data were analyzed using one-way ANOVA and Tukey post hoc tests (p≥0.05). In this study, oleuropein-Parkinson, swimming exercise-Parkinson, and swimming exercise with oleuropein-Parkinson consumption significantly decreased Malondialdehyde levels, significantly increased glutathione peroxidase activity and thiol compared to Parkinson's group (P<0/001). Swimming exercise with oleuropein consumption can improve antioxidant defense and decrease lipid peroxidation. Therefore, this interactive effect may necessitate more therapeutic and preventive treatment to prevent oxidative stress-related diseases.
