Articles in Press, Accepted Manuscript, Available Online from 20 November 2013
Abstract
Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin ...
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Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin (STZ) as a model of sporadic AD. In this research animals were divided randomly into 11 equal groups. Experimental model of AD was induced by bilateral icv injection of STZ. STZ-induced memory impairment was assessed two weeks after the last dose of STZ by using a passive avoidance task. The interval between the placement of animals in the illuminated chamber and the entry into the dark chamber was measured as step-through latency (STL). Castration was performed by surgical removing of testis and behavioral study of memory impairment was done after 4 weeks. Results of this study showed that icv injection of STZ could induce marked (p<0.001) memory impairment. Memory was worsened in castrated rats (P<0.001) when compared with normal and sham-operated animals. Testosterone replacement therapy in 4 week castrated rats restored memory up to the level of control groups. Testosterone had not any significant effect on memory impairments of non-castrated rats. According to the obtained results it can be concluded that testosterone improves cognitive and memory impairment of AD.
Animal physiology
Seyed Ebrahim Hosseini; Mozhde Heidari
Articles in Press, Accepted Manuscript, Available Online from 02 December 2013
Abstract
Introduction: Due to the increasing use of high intake of saturated fatty acids and their effects on overall physiological structures, effects of unsaturated fatty acids, including omega-3 and omega-6, and the proportion of these two together is essential physiological functions. Therefore, this study ...
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Introduction: Due to the increasing use of high intake of saturated fatty acids and their effects on overall physiological structures, effects of unsaturated fatty acids, including omega-3 and omega-6, and the proportion of these two together is essential physiological functions. Therefore, this study aimed to investigate the interaction of corn and salmon fish’s oil on avoidance learning in mature male rat.Method: In this empirical research work, we used 72 mature male rats weighing from 180-200g were enrolled as the control, sham and experiment groups. The control group was no treated. The sham group received only 1 ml saline, 6 experimental groups of different types received 0.5, 1 and 1.5 ml/kg body weight corn oil, and 0.25, 0.5 and 0.75 ml/kg body weight and 1 group other received doses of 0.5 and 1.5, salmon oil and corn oil respectively, daily for 28 days. For avoidance learning behavior, the rats were trained to shuttle box and 24 hours after training, the rats were tested retrieval. The data were evaluated using ANOVA.Results: The results showed that consumption of corn and salmon’s oil alone enhances learning and taking the time to arrange a 3 to 1 ratio, boost the oil alone is more than the avoidance learning.Discussion and conclusion: Omega-3 and Omega-6 fatty acids the rate 3 to 1, are most effective in promoting avoidance learning, so further investigation can be listed using ratios to enhance learning and prevention of Alzheimer's, it uses .
Fereshteh Keshavarzian; Abdolhassan Doulah; Maryam Rafieirad
Abstract
Parkinson is a chronic and widespread neurodegenerative disorder. In this study, the effects of swimming exercise and oleuropein supplementation on oxidative stress of brain tissue in experimental model of Parkinson's disease in rat were investigated. In this experimental study, 40 adult male Wistar ...
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Parkinson is a chronic and widespread neurodegenerative disorder. In this study, the effects of swimming exercise and oleuropein supplementation on oxidative stress of brain tissue in experimental model of Parkinson's disease in rat were investigated. In this experimental study, 40 adult male Wistar rats were selected and divided into five groups including: control group, Parkinson's group, swimming exercise, oleuropein consumption, swimming exercise with oleuropein consumption. The groups were forced to swim for 4 weeks (five sessions per week for 30 minutes each session) and groups 4 and 5 received 20 mg of oleuropein daily per kilogram of body weight orally for 4 weeks. Serum levels of the variables were evaluated using the thiobarbituric acid method. Data were analyzed using one-way ANOVA and Tukey post hoc tests (p≥0.05). In this study, oleuropein-Parkinson, swimming exercise-Parkinson, and swimming exercise with oleuropein-Parkinson consumption significantly decreased Malondialdehyde levels, significantly increased glutathione peroxidase activity and thiol compared to Parkinson's group (P<0/001). Swimming exercise with oleuropein consumption can improve antioxidant defense and decrease lipid peroxidation. Therefore, this interactive effect may necessitate more therapeutic and preventive treatment to prevent oxidative stress-related diseases.
Reza Azadbakht; Mohsen Jafarian Dehkordi; Soudeh Khanamani Falahati-Pour; Abdollah Ghasemi Pirbalouti; Sakineh Khanamani Falahatipour
Abstract
Abstract Pistacia khinjuk is one of the pistachio species and native medicinal plant of Iran. This plant has shown many pharmacological activities and has been used in traditional medicine for the treatment of various diseases. The present experimental study was designed to evaluate the effects of the ...
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Abstract Pistacia khinjuk is one of the pistachio species and native medicinal plant of Iran. This plant has shown many pharmacological activities and has been used in traditional medicine for the treatment of various diseases. The present experimental study was designed to evaluate the effects of the hydroalcoholic extract of khinjuk on the hematological parameters of rats. Eighteen male Wistar rats were divided into 3 six-member groups. Groups 1 to 3 were treated with 200 mg/kg bw of the extract, 400 mg/kg bw of the extract and distilled water (control group) for 30 days, respectively. Blood samples were then taken from the heart of the rats and hematological parameters were measured. To assess the significance of the difference in mean blood parameters between different groups, T test was performed at a significant level of P
Namdar Yousofvand; Vahid Hasanvand
Volume 7, Issue 1 , September 2018, , Pages 27-33
Abstract
Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and ...
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Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and food for 45 days and injected normal saline on 15th day. Control (diabetic by STZ at 40 mg/kg dose on 15th day) and the prevention group by garlic flower extract at a dose of 360 mg/Lit in drinking water received a treatment period for 15 days before diabetes. One dose of STZ 40mg/kg was injected intraperitoneally. The hematocrit of blood samples was measured, using the ABACUS-c Diatron device (Austria). Hematocrit showed a significant increase (p
Vahid Hasanvand; Namdar Yousofvand
Volume 6, Issue 4 , June 2018, , Pages 67-73
Abstract
Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water ...
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Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and food for 45 days and injected normal saline on 15th day. Control (diabetic by STZ at 40 mg/kg dose on 15th day) and the prevention group by garlic flower extract at a dose of 360 mg/Lit in drinking water received a treatment period for 15 days before diabetes. One dose of streptozotocin 40mg/kg was injected intraperitoneally. The hematocrit of blood samples was measured, using the ABACUS-c Diatron device (Austria). Hematocrit showed a significant increase (p
Samaneh Zolghadri Jahromi2; Majed Rezaeizadeh
Volume 6, Issue 3 , March 2018, , Pages 39-48
Abstract
The present study has investigated the effect of Iron nanoparticle on the ovary tissue lesion in the mice treated by isoniazid. In this study, 50 full-grown female rat divided randomly in five groups of eight rats. The control group received no treatment; the witness group received intraperitoneal (i.p.) ...
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The present study has investigated the effect of Iron nanoparticle on the ovary tissue lesion in the mice treated by isoniazid. In this study, 50 full-grown female rat divided randomly in five groups of eight rats. The control group received no treatment; the witness group received intraperitoneal (i.p.) isoniazid (50 mg/kg/bw , orally), group 2, group 3, and group 4 received 50 mg/kg isoniazid in combination with 150 and 250 mg/kg/bw respectively. Nanoparticles were intraperitoneally injected during 12 consequent days. After 24 hours, the nanoparticles in combination with isoniazid were injected again to the rats. On the 15th day, all groups were killed, dissected, and their ovaries removed for microscopic studies. After 15 days all rats were anatomized and their ovaries were taken out to be microscopically tested and put into ten percent formalin; the findings indicated the decrease of primary and secondary follicle (one and some layer), graph and yellow material in the group received isoniazid (P>0.05). The group received isoniazid and Nano ferrous oxide (150) show more significantly increase in primary and secondary follicles and graph and in the isoniazid and Nano ferrous oxide (250) primary, one layer, secondary and graph follicles show increase level compared to the isoniazid group (P>0.05). However, isoniazid had destroyed the ovary tissue in the groups who had received it and Nano ferrous oxide due to its antioxidant effects relatively decreased such effect.
S. R. Pourrabi1; A. R. Mohajjel Nayebi; S. E. Hossini
Volume 1, Issue 2 , November 2012, , Pages 25-32
Abstract
Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin ...
Read More
Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin (STZ) as a model of sporadic AD. In this research animals were divided randomly into 11 equal groups. Experimental model of AD was induced by bilateral icv injection of STZ. STZ-induced memory impairment was assessed two weeks after the last dose of STZ by using a passive avoidance task. The interval between the placement of animals in the illuminated chamber and the entry into the dark chamber was measured as step-through latency (STL). Castration was performed by surgical removing of testis and behavioral study of memory impairment was done after 4 weeks. Results of this study showed that icv injection of STZ could induce marked (p<0.001) memory impairment. Memory was worsened in castrated rats (P<0.001) when compared with normal and sham-operated animals. Testosterone replacement therapy in 4 week castrated rats restored memory up to the level of control groups. Testosterone had not any significant effect on memory impairments of non-castrated rats. According to the obtained results it can be concluded that testosterone improves cognitive and memory impairment of AD.
