In collaboration with Payame Noor University and Iranian Society of Physiology and Pharmacology

Document Type : Article

Authors

1 Resident of large animal internal medicine, Azad Islamic University, Science and Research Branch, Tehran, Iran

2 Assistant Professor, Department of Clinical Pathology, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

3 Assistant Professor, Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

4 Associated Professor, Center of Medicinal Plants Researches, Faculty of Agriculture, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

5 Assistant Professor, Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Abstract

Abstract

Pistacia khinjuk is one of the pistachio species and native medicinal plant of Iran. This plant has shown many pharmacological activities and has been used in traditional medicine for the treatment of various diseases. The present experimental study was designed to evaluate the effects of the hydroalcoholic extract of khinjuk on the hematological parameters of rats. Eighteen male Wistar rats were divided into 3 six-member groups. Groups 1 to 3 were treated with 200 mg/kg bw of the extract, 400 mg/kg bw of the extract and distilled water (control group) for 30 days, respectively. Blood samples were then taken from the heart of the rats and hematological parameters were measured. To assess the significance of the difference in mean blood parameters between different groups, T test was performed at a significant level of P

Highlights

 

References

 

Bozorgi, M.; Memariani, Z.; Mobli, M.; Salehi Surmaghi, MH.; Shams-Ardekani, MR.; Rahimi, R.; (2013). Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. The Scientific World Journal; 1-33.

Esmat, A.; Al-Abbasi, FA.; Algandaby, MM.; Moussa, AY.; Labib, RM.; Ayoub, NA.; Abdel-Naim, AB.; (2012). Anti-inflammatory activity of Pistacia khinjuk in different experimental models: isolation and characterization of its flavonoids and galloylated sugars. Journal of medicinal food; 15(3): 278-87.

Ezatpour B.; Saedi, Dezaki E.; Mahmoudvand, H.; Azadpour, M.; Ezzatkhah, F.; (2015). In vitro and in vivo antileishmanial effects of Pistacia khinjuk against Leishmania tropica and Leishmania major.  Evidence-Based Complementary and Alternative Medicine; 2015: 1-6.

Farzanegi, P.; Mousavi, M.; Ghanbari-Niaki, A.; (2013). Effect of Pistacia atlantica extract on glutathione peroxidase tissue levels and total oxidative capacity of liver and plasma lipid profile of rats. Zahedan Journal of Research in Medical Sciences; 15(11): 59-63.

Farzaneh, V.; Carvalho, IS.; (2015). A review of the health benefit potentials of herbal plant infusions and their mechanism of actions. Industrial Crops and Products; 65: 247-58.

Fattahi, A.; Sakvand, T.; Hajialyani, M.; Shahbazi, B.; Shakiba, M.; Tajehmiri, A.; Shakiba, E.; (2017). Preparation and Characterization of Pistacia khinjuk Gum Nanoparticles Using Response Surface Method: Evaluation of Its Anti-Bacterial Performance and Cytotoxicity. Advanced Pharmaceutical Bulletin; 7(1): 159-164.

Ghaedi, T.; Mirzaei, A.; Laameerad, B.; (2014). Protective effect of Pistacia khinjuk on gentamicin-induced nephrotoxicity in rats. World Journal of Pharmacy and Pharmaceutical Sciences; 3(2): 919-926.

Ghaseminasab, PM.; Ahmadi, A.; Mazloomi, SM.; (2015). A review on pistachio: its composition and benefits regarding the prevention or treatment of diseases. JOHE; 4(1): 57-69.

Hamedani, F.; Hadad Khodaparast, M.; Esmaeilzadeh Kenari, R.; ataei Salehi, E.; (2014). Comparison of chemical structure and thermal stability of pistacia khinjuk oil with olive oil as a new source of vegetable oil. New Food Technol; 2(5): 83-91. (in Persian)

Hamidi, SA.; Naeini, AT.; Oryan, A.; Tabandeh, MR.; Tanideh, N.; Nazifi, S.; (2007). Cutaneous Wound Healing after Topical Application of Pistacia atlantica Gel Formulation in Rats. Turkish Journal of Pharmaceutical Sciences; 14(1): 65-74.

Hashemi, SMB.; Khaneghah, AM.; Akbarirad, H.; (2016). The Effects of Amplitudes Ultrasound-Assisted Solvent Extraction and Pretreatment Time on the Yield and Quality of Pistacia Khinjuk Hull Oil. Journal of oleo science; 65(9): 733-8.

Jain, S.; Dwivedi, J.; Jain, PK.; Satpathy, S.; Patra, A.; (2016). Medicinal Plants for Treatment of Cancer: A Brief Review. Pharmacognosy Journal; 8(2): 87-102.

Kalantari, H.; Rezaei, M.; Mahdavinia, M.; Kalantar, M.; Amanpour, Z.; (2012). Determination of the mutagenicity potential of supermint herbal medicine by single cell gel electrophoresis in rat hepatocytes. Advanced pharmaceutical bulletin; 2(2): 245-248.

Mahmudzadeh, T.; Saghebjoo, M.; Seghatol Eslami, A.; Hedayati, M.; (2014). Effect of aerobic  training and pistacia atlantica extract consumption on pancreatic β-cells function in streptozotocin-induced diabetic rats. Iranian Journal of Diabetes and Metabolism; 13(3): 252-62.

Motamedi‐Tehrani, J.; Ebrahimi‐Dorcheh, E.; Malekpouri, P.; Goli, S.; (2016). Liver alteration and hematological and serum biochemical responses of common carp, Cyprinus carpio Linnaeus, 1758, following long‐term feeding of pistachio (Pistacia vera) green hull extract as a source of natural phenol. Journal of Applied Ichthyology; 32(5): 906-12.

Peksel, A.; Arisan‐Atac, I.; Yanardag, R.; (2010). Evaluation of antioxidant and antiacetylcholinesterase activities of the extracts of Pistacia atlantica Desf. Leaves. Journal of Food Biochemistry; 34(3): 451-76.

Rout, SP.; Choudary, K.; Kar, D.; Das, L.; Jain, A.; (2009). Plants in traditional medicinal system-future source of new drugs. Int J Pharm Pharm Sci; 1(1): 1-23.

Tahvilian, R.; Moradi, R.; Hajialiani, M.; Zangeneh, M.; Zangeneh, A.; Yazdani, H.; Zhaleh, H.; (2016). Chemical composition and screening of antibacterial activities of essential oil of Pistacia khinjuk against Bacillus subtilis (ATCC No. 21332). International Journal of Current Medical and Pharmaceutical Research; 2(12): 1098-102.

Taran, M.; Azizi, E.; Shikhvaisi, A.; Asadi, N.; (2009). The anthelmintic effect of Pistacia khinjuk against protoscoleces of Echinococcus granulosus. World Journal of Zoology; 4(4): 291-5.

Taran, M.; Sharifi, M.; Azizi, E.; Khanahmadi, M.; (2010). Antimicrobial activity of the leaves of Pistacia khinjuk. Journal of Medicinal Plants; 1(33): 81-5.

Taran, M.; Mohebali, M.; Esmaeli, J.; (2010). In vivo efficacy of gum obtained Pistacia atlantica in experimental treatment of cutaneous leishmaniasis. Iranian journal of public health; 39(1): 36.

Tohidi, M.; Khayami, M.; Nejati, V.; Meftahizade, H.; (2011). Evaluation of antibacterial activity and wound healing of Pistacia atlantica and Pistacia khinjuk. Journal of Medicinal Plants Research; 5(17): 4310-4.

Tolooei, M.; Mirzaei, A.; (2015). Effects of Pistacia Atlantica extract on erythrocyte membrane rigidity, oxidative stress, and hepatotoxicity induced by CCl4 in rats. Global journal of health science; 7(7): 32.

 

Keywords

 
References
 
Bozorgi, M.; Memariani, Z.; Mobli, M.; Salehi Surmaghi, MH.; Shams-Ardekani, MR.; Rahimi, R.; (2013). Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. The Scientific World Journal; 1-33.
Esmat, A.; Al-Abbasi, FA.; Algandaby, MM.; Moussa, AY.; Labib, RM.; Ayoub, NA.; Abdel-Naim, AB.; (2012). Anti-inflammatory activity of Pistacia khinjuk in different experimental models: isolation and characterization of its flavonoids and galloylated sugars. Journal of medicinal food; 15(3): 278-87.
Ezatpour B.; Saedi, Dezaki E.; Mahmoudvand, H.; Azadpour, M.; Ezzatkhah, F.; (2015). In vitro and in vivo antileishmanial effects of Pistacia khinjuk against Leishmania tropica and Leishmania major.  Evidence-Based Complementary and Alternative Medicine; 2015: 1-6.
Farzanegi, P.; Mousavi, M.; Ghanbari-Niaki, A.; (2013). Effect of Pistacia atlantica extract on glutathione peroxidase tissue levels and total oxidative capacity of liver and plasma lipid profile of rats. Zahedan Journal of Research in Medical Sciences; 15(11): 59-63.
Farzaneh, V.; Carvalho, IS.; (2015). A review of the health benefit potentials of herbal plant infusions and their mechanism of actions. Industrial Crops and Products; 65: 247-58.
Fattahi, A.; Sakvand, T.; Hajialyani, M.; Shahbazi, B.; Shakiba, M.; Tajehmiri, A.; Shakiba, E.; (2017). Preparation and Characterization of Pistacia khinjuk Gum Nanoparticles Using Response Surface Method: Evaluation of Its Anti-Bacterial Performance and Cytotoxicity. Advanced Pharmaceutical Bulletin; 7(1): 159-164.
Ghaedi, T.; Mirzaei, A.; Laameerad, B.; (2014). Protective effect of Pistacia khinjuk on gentamicin-induced nephrotoxicity in rats. World Journal of Pharmacy and Pharmaceutical Sciences; 3(2): 919-926.
Ghaseminasab, PM.; Ahmadi, A.; Mazloomi, SM.; (2015). A review on pistachio: its composition and benefits regarding the prevention or treatment of diseases. JOHE; 4(1): 57-69.
Hamedani, F.; Hadad Khodaparast, M.; Esmaeilzadeh Kenari, R.; ataei Salehi, E.; (2014). Comparison of chemical structure and thermal stability of pistacia khinjuk oil with olive oil as a new source of vegetable oil. New Food Technol; 2(5): 83-91. (in Persian)
Hamidi, SA.; Naeini, AT.; Oryan, A.; Tabandeh, MR.; Tanideh, N.; Nazifi, S.; (2007). Cutaneous Wound Healing after Topical Application of Pistacia atlantica Gel Formulation in Rats. Turkish Journal of Pharmaceutical Sciences; 14(1): 65-74.
Hashemi, SMB.; Khaneghah, AM.; Akbarirad, H.; (2016). The Effects of Amplitudes Ultrasound-Assisted Solvent Extraction and Pretreatment Time on the Yield and Quality of Pistacia Khinjuk Hull Oil. Journal of oleo science; 65(9): 733-8.
Jain, S.; Dwivedi, J.; Jain, PK.; Satpathy, S.; Patra, A.; (2016). Medicinal Plants for Treatment of Cancer: A Brief Review. Pharmacognosy Journal; 8(2): 87-102.
Kalantari, H.; Rezaei, M.; Mahdavinia, M.; Kalantar, M.; Amanpour, Z.; (2012). Determination of the mutagenicity potential of supermint herbal medicine by single cell gel electrophoresis in rat hepatocytes. Advanced pharmaceutical bulletin; 2(2): 245-248.
Mahmudzadeh, T.; Saghebjoo, M.; Seghatol Eslami, A.; Hedayati, M.; (2014). Effect of aerobic  training and pistacia atlantica extract consumption on pancreatic β-cells function in streptozotocin-induced diabetic rats. Iranian Journal of Diabetes and Metabolism; 13(3): 252-62.
Motamedi‐Tehrani, J.; Ebrahimi‐Dorcheh, E.; Malekpouri, P.; Goli, S.; (2016). Liver alteration and hematological and serum biochemical responses of common carp, Cyprinus carpio Linnaeus, 1758, following long‐term feeding of pistachio (Pistacia vera) green hull extract as a source of natural phenol. Journal of Applied Ichthyology; 32(5): 906-12.
Peksel, A.; Arisan‐Atac, I.; Yanardag, R.; (2010). Evaluation of antioxidant and antiacetylcholinesterase activities of the extracts of Pistacia atlantica Desf. Leaves. Journal of Food Biochemistry; 34(3): 451-76.
Rout, SP.; Choudary, K.; Kar, D.; Das, L.; Jain, A.; (2009). Plants in traditional medicinal system-future source of new drugs. Int J Pharm Pharm Sci; 1(1): 1-23.
Tahvilian, R.; Moradi, R.; Hajialiani, M.; Zangeneh, M.; Zangeneh, A.; Yazdani, H.; Zhaleh, H.; (2016). Chemical composition and screening of antibacterial activities of essential oil of Pistacia khinjuk against Bacillus subtilis (ATCC No. 21332). International Journal of Current Medical and Pharmaceutical Research; 2(12): 1098-102.
Taran, M.; Azizi, E.; Shikhvaisi, A.; Asadi, N.; (2009). The anthelmintic effect of Pistacia khinjuk against protoscoleces of Echinococcus granulosus. World Journal of Zoology; 4(4): 291-5.
Taran, M.; Sharifi, M.; Azizi, E.; Khanahmadi, M.; (2010). Antimicrobial activity of the leaves of Pistacia khinjuk. Journal of Medicinal Plants; 1(33): 81-5.
Taran, M.; Mohebali, M.; Esmaeli, J.; (2010). In vivo efficacy of gum obtained Pistacia atlantica in experimental treatment of cutaneous leishmaniasis. Iranian journal of public health; 39(1): 36.
Tohidi, M.; Khayami, M.; Nejati, V.; Meftahizade, H.; (2011). Evaluation of antibacterial activity and wound healing of Pistacia atlantica and Pistacia khinjuk. Journal of Medicinal Plants Research; 5(17): 4310-4.
Tolooei, M.; Mirzaei, A.; (2015). Effects of Pistacia Atlantica extract on erythrocyte membrane rigidity, oxidative stress, and hepatotoxicity induced by CCl4 in rats. Global journal of health science; 7(7): 32.