In collaboration with Payame Noor University and Iranian Society of Physiology and Pharmacology

Document Type : Article

Authors

1 Assistan Professor, Department of Biology, Payame Noor University, Tehran, Iran

2 M.A. of Biochemistry, Department of Biology, Payame Noor university, Tehran, Iran

3 Assistant Professor, Department of Mathematics, Payame Noor University, Tehran, Iran

Abstract

Abstract
The most common diseases are neonatal jaundice at birth which leads to a yellowish skin of the infants and the white eye due to an increase in the amount of bilirubin in the baby's blood. Naturally, bilirubin passes through the liver and is excreted as bile from the intestine. Neonatal jaundice occurs when bilirubin is produced earlier than the ability of the neonate liver to decompose and dispose of it. The aim of study was to determine the prevalence of neonatal jaundice and its risk factors.
In this descriptive study, 1000 neonates hospitalized to the Neonatal Department of Maryam Hospital of Karaj were examined by easy non-probability sampling. Total bilirubin, G6PD, hemoglobin, RH, blood group, as well as gender and delivery method. In this study, 36% of infants were affected by jaundice. The lack of G6PD activity in jaundice was 10.5%. The prevalence of preterm jaundice was ABO incompatibility, RH incompatibility and G6PD deficiency. The age and weight of the infant at the time of visit, the incidence of jaundice and the weight of the baby at 3 to 10 days in the groups were not significantly different. The mean of bilirubin in infants born with normal delivery was 3.8 and in cesarean section were 11.2. Amount of jaundice and its severity in neonates of cesarean section is higher. Total bilirubin in female neonates did not differ significantly with males. Part of the prevalence of jaundice was due to abnormality of ABO and RH and deficiency of the G6PD enzyme. The results show that other factors also affect jaundice. Approximately 80% of infants who lack the G6PD enzyme deficiency or incompatibility of the blood group showed that the level of bilirubin was much lower than that of normal infants.
 

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