Document Type : Article
Author
Abstract
Injection of sulpiride (D2 receptor antagonist, antipsychotic drug) into VMN hypothalamus, increased gastric volume secretion and decreased gastric pH. The present study the effect of SCH23390 (D1 dopamine receptor antagonist) on the gastric acid secretion and its acidity were studied. 70 rats were divided into 7 groups: two control groups, two sham groups given medicine solvents, a SCH23390 group (7.5µg), and bromocriptine group (25µg) and a mixed group: SCH23390 7.5µg along with bromocriptine 25µg. Gastric secretion volume was taken by syringe 2CC and by using SPSS program the groups were compared (Test Anova). Results showed that SCH23390 group (7.5µg) could increase volume of gastric secretion and decrease gastric acidity, while Bromocriptine (25µg) could not affect gastric volume secretion and its acidity. However, bromocriptine (25µg) along with SCH23390 7.5µg significantly increased gastric volume secretion and its acidity. There for the dopaminergic system of the VMN has a considerable effect on the secretion of the exocrine glands in the digestive system.
Keywords
Main Subjects
Abbasnejad, M.; Karimian, S.M.; Zarrindast, M.R.; Faghihi, M.; & Bahram, P; (2001). The Effects of bromocriptine injection in ventromedial nucleus of hypothalamus on food and water intake as well as gain in adult male rats. Cell J (Yakhteh); 3(2): 97-102.
Ahima, R.S.; Osei, S.Y; (2001). Molecular regulation of eating behavior: new insights and prospects for therapeutic strategis. Trends Mol Med; 7(5): 205-8.
Akubuiro, A.; Bridget Zimmerman, M.; Boles Ponto, LL.; Walsh, SA.; Sunderland, J.; McCormick, L.; Singh, M; (2013). Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice. Genes Brain Behav; 12(3): 311-22.
Baptista, T.; Molina, MG.; Martinez, J.L.; de Quijada, M.; Calanche de, Cuesta, I.; Acosta, A; (1997). Effects of the antipsychotic drug sulpiride on reproductive hormones in healthy premenopausal women: relationship with body weight regulation. Pharmacopsychiatry; 30(6): 256-62.
Baptista, T.; Contreras, Q.; Teneud, L.; Albornoz, M.A.; Aciosta, A; (1998). Mechanism of the neuroleptic-induced obesity in female rats. Prog Neuropsychopharmacol Biol Psychiatry 22(1): 187-198.
Baptistaa, T.; de. Baptistab, E.A.; Lalonde, J.; Plamondon, J.; Kin, N. M.; Beaulieu, S; (2004). Comparative effects of the antipsychotics sulpiride and risperidone in female rats on energy balance, body composition, fat morphology and macronutrient selection. Prog Neuropsychopharmacology Biol Psychiatry; 28(8): 1305-1311.
Bourne, J.A; (2001). SCH 23390: The First Selective Dopamine D1-Like Receptor Antagonist. Neva Press, Branford, Connecticut; 7(4): 399-414.
Bern, R.M.; Levy, M.N; (2012). Medical Physiology. (4th edition): USA-Mosby year book: 58- 908.
Cone, R.D; (1999). The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 10(6):211-216.
Feldman, R.S; Meyer, J.S; Qenzer, L.F; (1997). Principles of neuropsychopharmachology. United State of America. Sinauer 239-307.
Fetissov, S.O.; Meguid, M.M.; Sato. T.; Zhang. L.H; (2002). Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake. Am J Physiol Regul Integr Comp Physiol; 283(4): R905-10.
Ingole, S.; Belorkar, N.R.; Waradkar, P.; Shrivastava, M; (2009). Comparison of effects of olanzapine and risperidone on body mass index and blood sugar level in schizophrenic patients. Indian J Physiol Pharmacol; 53(1): 47-54.
Lodge, D.J.; Grace, A.A; (2011). Developmental pathology, dopamine, stress and schizophrenia. Int J Dev Neurosci; 29(3): 207-213.
Moradi, M.; Yazdian, MR.; Haghparast, A; (2014). Lateral hypothalamus chemical stimulation-induced antinociception was attenuated by injection of dopamine D1 and D2 receptor antagonists in the ventral tegmental area. Physiology and Pharmacology; 18(1): 36-46.
Ozdemir, V.; Jamal, M.M.; Osapay, K.; Jadus, M.R.; Sandor, Z.; Hashemzadeh, M.; Szabo, S; (2007). Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: revisiting the “brain-gut axis” hypothesis in ulcer pathogenesis. J Investing Med, 55(6): 315-320.
Parada, M.A.; Hernandez, L.; Puig de parade, M.; Paez, X.; Hobel, B.G; (1990). Dopamin in the lateral Hypothalamus may be involved in the inhibition of locomotion related to food and water seeking. Brain Res Bull; 25(6): 961-8.
Paxinos, G.; Keith, B; (2004). Franklin J. The Mouse Brain in Stereotaxic Coordinates: Gulf Professional Publishing.
Patel, N.C.; Kistler, J.S.; James, E.B.; Crismon, M.L; (2004). A retrospective analysis of the short-term effects of olanzapine and quetiapine on weight and body mass index in children and adolescents. Pharmacotherapy 24(7): 824-30.
Rasheed, M.; Al Ghasham, A; (2012). Central dopaminergic system and its implications in stress-mediated neurological disorders and gastric ulcers: Short Review. Adv in Pharma Sci; 1-10.
Rasheed, N.; Ahmad, A.; Singh, N.; Singh, P.; Mishra, V.; Banu, N; (2010). Differential response of A 68930 and sulpiride in stress-induced gastric ulcers in rats. Eur J Pharmacol; 643(1): 121-128.
Toushih, M.; Shahbazi, F.; Ghajarzadeh, M.; Vahedi, Mazdabadi N; (2014). The Effect of sulpiride and bromocriptine injection into ventromedial nucleus of hypothalamus on the volume and acidity of gastric acid secretion in the rat. Experimental Animal Biology Journal; 10(2): 75-82.
Venkateshwarlu, G.; Sathis Kumar, D.; Sravan Prasad M.; Vijay Bhasker, K.; Gowrishanker, N.L.; Bhaskar, J; (2011). Antiulcer activity of leaf extract of Piliostigma thonningii in Albino Rats. Euro J Biol Sci; 3(1): 22-24.
Wang, G.J.; Volkow, N.D.; Fowler, J.S; (2002). The role of dopamine in motivation for food in humans: implications for obesity. Expert Opin Ther Targets; 6(5): 601-9.
Yoshica, K.; Yoshida, T.; Wakabayashi, Y.; Nishioka, H.; Kondo, M; (1989). Effects of exercise training on brown adipose tissue thermogenesis in overiectomised obes rats. Endocrinal Jpn; 36(3): 403-408.
Zendehdel, M.; Babapour, V.; Asadi, S; (2007). Effects of intracerebroventricular injections of glucose and insulin on food intake in chicken. OFOGh-E- DANESH 13(1): 22-27.
)