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Study the antioxidant activity of Zataria multiflora essential oils on hepatotoxicity induced by iron nanoparticles

Document Type : Article

Authors

1 Professor of Biochemistry Department, Faculty of Science, Payame Noor University, Tehran, Iran

2 M.Sc. Student, Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran

3 Ph.D Candidate of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran

4 Professor assistant, Faculty of Science, Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran

Abstract


Background and Objective: In the present study, we investigated the protective effects of Zataria multiflora essential oil against iron nano particle induced liver damage in rats. The animals were divided into three groups: negative control group; animals were treated with normal salin in three days. poitive control group: 200 mg/kg b.w iron nano particle was administered intrapertoneally to male in three days. Treatment group with Zataria multiflora oil; animals were injected intraperitoneally with Zataria multiflora oils (100 and 200 mg/kg b.w) in three days. After three days, blood samples were drawn from heart and the liver tissues were removed for biochemical and histological studies. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate amino transferas (AST), alkalin phosphatase (ALP), Ferric Reducing Ability of Plasma (FRAP), lipid peroxidation (LP) and glutathione (GSH). The results of this study showed that iron nano particles caused increasing the serum AST and LP levels and decreasing FRAP and GSH levels, but it has no effect on ALT and ALP. Consumption of Zataria multiflora oil reversed AST, LP and GSH levels to the normal levels without any effect on FRAP.  Finally, treatment of rats with iron nanoparticle caused induction of oxidative hepatic damage and consumption of zataria essential oil can be effective for the recovery and prevent of liver damage.

Keywords

References
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Experimental animal Biology
Volume 6, Issue 3 - Serial Number 3
March 2018
Pages 49-59
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