Document Type : Article
Authors
1 Associate Professor in Department of Basic Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
2 Ph.D. Student in physiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Abstract
Chronic cyanide intoxication has been shown to induce damage in various tissues. In the present study the effects of chronic exposure to potassium cyanide (KCN) on some oxidative stress-related parameters as well as Modulatory effects of garlic powder were studied. 18 male wistar rats were assigned into three groups, 6 in each group. Group 1 served as control group. Group 2 received cyanide (KCN, 500 mg/L) in drinking water for 42 days. Rats in Group 3 received water containing KCN (500 mg/L in drinking) and also were fed a diet containing 5% garlic powder for 42 days. Cyanide caused increase in malondialdehyde (MDA) concentartins in all studies tissues, although the increase was only significant (P has modulatory effect on cyanide-induced oxidative stress damage in rat and could have therapeutic and prophylactic effects on cyanide poisoning.
Keywords
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