In collaboration with Payame Noor University and Iranian Society of Physiology and Pharmacology

Document Type : Article

Authors

1 M. Sc. Student, Department of Biology, Jahrom Branch, Islamic Azad University, Jahrom, Iran and Young Researchers and Elite Club, Jahrom Branch, Islamic Azad University, Jahrom, Iran

2 Assistant Professor, Department of physiology, Fasa University of Medical Sciences, Fasa, Iran

Abstract

GABA is a neurotransmitter that is an essential role in the inhibition of pain and GABA signals responsible for chronic pain. Parabrachial nucleus is involved in cognitive and emotional aspects of pain. The purpose of this study is to evaluate the inhibitory effect of bicuculline on the fusiform neurons of the parabrachial nucleus on tonic pain model in rats. In this study, 35 male Wistar rats weighting approximately 250-300g were divided into four groups: Control, 50, 100 and 200 ng/rat. Bicycling was injected through the cannula in Parabrachial area using a Hamilton syringe and polyethylene tubing. Formalin tests were used in this study and then fusiform cells were counted using hematoxylin and eosin staining. The fusiform cells in Control and the doses of 50 and 100 ng/rat groups did not change significantly, but in the dose of 200ng group, the cells in parabrachial nucleus were significantly reduced (p

Keywords

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