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Evaluation of serum amylase levels in patients with occult blood ‎in stool (positive OB); prognosis of malignant gastrointestinal ‎diseases

Document Type : Article

Authors

1 Department of Biology, Payame Noor University, Tehran, Iran

2 Department of Biology, Payame Noor ‎University, Tehran. Iran

10.30473/eab.2025.73883.1990

Abstract

The most widely used colon cancer screening test is the diagnostic test for checking the presence of blood in stool. This test is utilized to examine the occult blood sample present in the stool or the blood compounds that may arise in the event of minor bleeding within the digestive tract. In this study, the serum amylase levels of OB-positive patients (with occult blood in the stool) were examined as a predictor of gastrointestinal malignancies. Ninety individuals aged 50 and over who referred to the laboratory department of Tabriz Alinasab Hospital were divided into three groups: healthy control, OB positive patients, and patients with colorectal cancer. The measurement of serum amylase was performed using the enzymatic calorimetric (photometric) method, using the Man company diagnostic kits and the BS-800M autoanalyzer. Data analysis was performed using SPSS software, and the ANOVA test was used to show the relationship between variables. The healthy group did not exhibit a significantly different serum amylase level from that of OB-positive patients who didn’t exhibit colorectal cancer symptoms. The amount of serum amylase in patients with colorectal cancer increased significantly compared to the healthy group (p<0.05). In patients with colorectal cancer, a significant increase in serum amylase levels was observed compared to OB positive patients without colorectal cancer symptoms (p<0.05). It’s possible to conclude that a positive occult blood doesn’t always indicate cancer. Positive occult blood in the stool increases the risk of developing various diseases. Therefore, other patients with occult blood in the stool should be given a colonoscopy more seriously.

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References
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Experimental animal Biology
Volume 13, Issue 4 - Serial Number 52
October 2025
Pages 67-75
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