Payame Noor University Experimental animal Biology 2322-2387 7 3 2018 12 22 Effect of zinc chloride on anxiety and deppresive behaviors gonadectomized peri-pubertaly male rats Effect of zinc chloride on anxiety and deppresive behaviors gonadectomized peri-pubertaly male rats 79 88 5327 10.30473/eab.2018.5327 FA Pooran Ghahramani M. A., Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran Hooman Eshagh Harooni Assistant Professor, Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran Seyed Raza Fatemi Tabatabaei Associate Professor, Department of Physiology, Shahid Chamran University of Ahvaz, Ahvaz, Iran Ahmad Ali Moazedi Journal Article 2019 01 05 <strong>Abstract</strong> <br />Anxiety is a common disease in the society. About 500 million people worldwide suffer from this disorder. 85% of people with depression also have anxiety. According to anxiolytic effects of different zinc chloride in male and female rats is Castration post- pubertaly, this was investigated, the effect of zinc chloride on anxiety and deppresive behaviors of rats, in gonadectomized peri-pubertaly. In this experiment, fifty male rats were gonadectomized at postnatal day 21-22 and at puberty were divided into Six groups, control, sham (saline), gonadectomized (saline) and the gonadectomized groups receiving Zinc chloride 5, 10 and 20 mg/kg. Then on postnatal day 75, different doses of zinc chloride (5, 10 and 20 mg/kg; IP) were administered 30 min before the elevated plus maze and forced swimming test. The results showed in gonadectomized group (saline) anxiety did not reach to a significant criterion. Zinc chloride (20 mg/kg) significantly increase the time spent in the open arms in gonadectomized (20 mg/kg) group compared to the gonadectomized group (p<strong> </strong> <strong>Abstract</strong> <br />Anxiety is a common disease in the society. About 500 million people worldwide suffer from this disorder. 85% of people with depression also have anxiety. According to anxiolytic effects of different zinc chloride in male and female rats is Castration post- pubertaly, this was investigated, the effect of zinc chloride on anxiety and deppresive behaviors of rats, in gonadectomized peri-pubertaly. In this experiment, fifty male rats were gonadectomized at postnatal day 21-22 and at puberty were divided into Six groups, control, sham (saline), gonadectomized (saline) and the gonadectomized groups receiving Zinc chloride 5, 10 and 20 mg/kg. Then on postnatal day 75, different doses of zinc chloride (5, 10 and 20 mg/kg; IP) were administered 30 min before the elevated plus maze and forced swimming test. The results showed in gonadectomized group (saline) anxiety did not reach to a significant criterion. Zinc chloride (20 mg/kg) significantly increase the time spent in the open arms in gonadectomized (20 mg/kg) group compared to the gonadectomized group (p<strong> </strong> https://eab.journals.pnu.ac.ir/article_5327_66a3d74dd62657dae2c202df6a116804.pdf