Animal physiology
Articles in Press, Accepted Manuscript, Available Online from 20 November 2013
Abstract
Background: Obesity is often associated with micronutrient deficiency, the result of poor diet, lack of antioxidants and polyunsaturated fat on one side and saturated fats, on the other side. Oxidative stress has a role in the onset of chronic diseases associated with obesity.Plant-derived secondary ...
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Background: Obesity is often associated with micronutrient deficiency, the result of poor diet, lack of antioxidants and polyunsaturated fat on one side and saturated fats, on the other side. Oxidative stress has a role in the onset of chronic diseases associated with obesity.Plant-derived secondary metabolites such as phenolics and total flavonoids may have potential for free radical scavenging. The purpose of this study was to determine the effect of natural compounds such as thymol, acarbose,thioflavin T and Chalcone on serum total antioxidant levels in mice obese.Methods: This study was performed in NMRI male mice. Animals were randomly divided into two groups: a control group (receiving standard rodent diet) and experimental group for 8 weeks (receiving high-calorie diet group).The obese animals into three groups: sham,obese and experimental groups. In the experimental group of mice with compounds thymol, acarbose, thioflavin T and Chalcone(12mg/kg/day) were gavage for 8 weeks.The end of treatment, blood samples, to investigate serum total antioxidant capacity (Total Antioxidant Capacity, TAC) was performed .Results: Antioxidant capacity decreased in the obese group, the sham TAC levels than obese and control increased. In all treatment groups, TAC levels increased, but this increase in the thioflavin and chalcone group compared with the other groups was not significant; but in acarbose group (P
Animal physiology
Articles in Press, Accepted Manuscript, Available Online from 01 December 2013
Abstract
The association between ABO blood groups and Helicobacter pylori seroprevalence is still controversial. We aimed to study the association between ABO/Rh antigens and IgG seropositivity in an Iranian adult population for the first time. Blood samples of 300 healthy young adults aging 18 -30 years were ...
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The association between ABO blood groups and Helicobacter pylori seroprevalence is still controversial. We aimed to study the association between ABO/Rh antigens and IgG seropositivity in an Iranian adult population for the first time. Blood samples of 300 healthy young adults aging 18 -30 years were collected for H. pylori antibody detection and ABO/Rhesus blood group antigen typing. 51.2 %, 49.5 %, 52.5 % and 60.0 % of cases with blood groups O, A, B and AB were seropositive, respectively. The frequency of seropositivity was not statistically different among the four blood groups (P = 0.843). No association was found between seropositivity and either Rh antigen (P = 0.850) or gender (P = 0.377). Seropositive individuals were significantly older than seronegative ones (24.48 ± 3.72 years vs. 23.25 ± 3.88 years; P = 0.006). There was a sharp increase in the prevalence of seropositivity in the 21-24 year age group compared to the 18-21 year age group and in the 27-30 year age group compared to 24-27 year age group. Adults in Iran seem to be more prone to new H. pylori infection in the beginning and the end of their twenties than the years in between.
Animal physiology
Seyed Ebrahim Hosseini; Mozhde Heidari
Articles in Press, Accepted Manuscript, Available Online from 02 December 2013
Abstract
Introduction: Due to the increasing use of high intake of saturated fatty acids and their effects on overall physiological structures, effects of unsaturated fatty acids, including omega-3 and omega-6, and the proportion of these two together is essential physiological functions. Therefore, this study ...
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Introduction: Due to the increasing use of high intake of saturated fatty acids and their effects on overall physiological structures, effects of unsaturated fatty acids, including omega-3 and omega-6, and the proportion of these two together is essential physiological functions. Therefore, this study aimed to investigate the interaction of corn and salmon fish’s oil on avoidance learning in mature male rat.Method: In this empirical research work, we used 72 mature male rats weighing from 180-200g were enrolled as the control, sham and experiment groups. The control group was no treated. The sham group received only 1 ml saline, 6 experimental groups of different types received 0.5, 1 and 1.5 ml/kg body weight corn oil, and 0.25, 0.5 and 0.75 ml/kg body weight and 1 group other received doses of 0.5 and 1.5, salmon oil and corn oil respectively, daily for 28 days. For avoidance learning behavior, the rats were trained to shuttle box and 24 hours after training, the rats were tested retrieval. The data were evaluated using ANOVA.Results: The results showed that consumption of corn and salmon’s oil alone enhances learning and taking the time to arrange a 3 to 1 ratio, boost the oil alone is more than the avoidance learning.Discussion and conclusion: Omega-3 and Omega-6 fatty acids the rate 3 to 1, are most effective in promoting avoidance learning, so further investigation can be listed using ratios to enhance learning and prevention of Alzheimer's, it uses .
Veterinary
mokhtar fathi
Articles in Press, Accepted Manuscript, Available Online from 02 December 2013
Abstract
A study with 160 one-day age male broilers (Ross 308) was for six week period, conducted to investigate the some blood parameters, and plasma thyroxin (T4) and triiodothyronine (T3) of broiler chickens with cold induced pulmonary hypertension syndrome (PHS). Chicks in 2 groups of 4 replicates were studied ...
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A study with 160 one-day age male broilers (Ross 308) was for six week period, conducted to investigate the some blood parameters, and plasma thyroxin (T4) and triiodothyronine (T3) of broiler chickens with cold induced pulmonary hypertension syndrome (PHS). Chicks in 2 groups of 4 replicates were studied in each group20 chicks for each replicate were used. One group set as control (healthy) group and reared under normal temperature, second group set as PHS group and reared under cold temperature. At the end of the experiment (day42), 2 chicks from each replicate were randomly selected bled and slaughtered. The heart was removed and the right ventricle was dissected away. The ratio of right ventricle weight to total ventricle weight (RV/TV) was calculated. The results showed that hematocrit value, mortality due to ascites, RV/TV index and differential white blood cells count were significantly higher in CT treatment chick (P˂0.05). The concentrations of plasma t4 of CT birds were significantly lower than other group birds at day 21 & 42. it is also, The concentrations of plasma t3 of CT birds were significantly higher than other group birds at day 21(exception day 42) (P˂0.05).
Animal physiology
Seyed Ebrahim Hosseini; Elham Rezaei; Davood Mehrabani
Articles in Press, Accepted Manuscript, Available Online from 19 October 2014
Abstract
Increasing the levels of blood lipids is the most common factors in diabetes that will exacerbate its complications. PJ (Pomegranate juice) is a nutrient with medical purposes. The present study aimed to investigate the effects of pomegranate juice on levels of triglycerides, cholesterol; LDL and HDL ...
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Increasing the levels of blood lipids is the most common factors in diabetes that will exacerbate its complications. PJ (Pomegranate juice) is a nutrient with medical purposes. The present study aimed to investigate the effects of pomegranate juice on levels of triglycerides, cholesterol; LDL and HDL in healthy and diabetic adult male rats were done. In the study, 90 adult male rats weighing 220-200 g were divided into groups of control, diabetic and non-diabetic experimental groups. Each group includes 9 mice. Experimental groups received respectively 1, 2 and 4 ml of pomegranate juice per rat for 21 days. To create diabetes by Intra-peritoneal injection, streptozotocin 60mg/kg was used. At the end of experiment by the phlebotomizing the animal hearts, serum levels of triglycerides, cholesterol, LDL and HDL were measured. Data were analyzed by ANOVA and LSD tests. The results showed that pomegranate juice in doses of 2 and 4 ml caused a significant reduction in triglyceride levels, respectively, in the P
Biochemistry
Articles in Press, Accepted Manuscript, Available Online from 19 October 2014
Abstract
Background: Based on the limited and inconsistent results about the effects of exercise on inflammatory markers in serum and saliva, this study was conducted to comparing of serum and saliva C-reactive protein (CRP) and interleukin-6 responses in healthy men following one bout exhaustive aerobic exercise.Methods: ...
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Background: Based on the limited and inconsistent results about the effects of exercise on inflammatory markers in serum and saliva, this study was conducted to comparing of serum and saliva C-reactive protein (CRP) and interleukin-6 responses in healthy men following one bout exhaustive aerobic exercise.Methods: In a quasi-experimental pre/post design, twenty two volunteer healthy men (aged 20-30 years and body fat 10-16%) participated in an exhaustive aerobic exercise (Bruce treadmill test). Serum and saliva samples were collected immediately before and after the exercise test. C-reactive protein was determined by immunophotometry and IL-6 was determined by ELISA method. Data were expressed as mean (±SD) and analyzed by t-test and Spearman's correlation coefficient at α≤0.05. Results: The results show that the serum and saliva CRP and IL-6 were significantly increased (P
Animal physiology
ramesh monagemi; noushin naghsh
Articles in Press, Accepted Manuscript, Available Online from 19 October 2014
Abstract
Cervical cancer is the most common gynecologic cancer and the second most common cancer in women worldwide. Herbal preparations are used to treat cancer for centuries. The aim of this study was investigate the cytotoxic effects of the methanol extract of Citrullus Colocynthis and volatile oils of Iranian ...
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Cervical cancer is the most common gynecologic cancer and the second most common cancer in women worldwide. Herbal preparations are used to treat cancer for centuries. The aim of this study was investigate the cytotoxic effects of the methanol extract of Citrullus Colocynthis and volatile oils of Iranian C. medica on Hela cell line. After preparation extract and volatile oils, different concentrations of volatile oils of C. medica (0.25-10 μg / ml) and extract of Citrullus Colocynthis (100-1000 μg / ml) were added to Hela cultured cells and incubated for 72 hours. Cell survival was evaluated using MTT-based cytotoxicity assay. The results showed that methanolic extract of Citrullus Colocynthis had not significant cytotoxic effect on Hela cells but Volatile oils of Citrus medica had significant cytotoxic effect on this cells and it’s most compounds was limonene , linalool , linalool acetate and beta - pinene. The findings showed that volatile oils of C. medica had more cytotoxic effect than the Citrullus Colocynthis extract, limonene and linalool of the volatile oil causes this effects.
Animal physiology
Morvarid Shafeii; Fereshteh Dadfar; Aazam Karami
Abstract
Considering the importance and undeniable impact of air pollution on human health, the purpose of this research was to investigate the effect of respiratory pollutants on blood parameters and general health of Hormuz Petrochemical personnel in Assalouye. In this experimental research, 60 male employees ...
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Considering the importance and undeniable impact of air pollution on human health, the purpose of this research was to investigate the effect of respiratory pollutants on blood parameters and general health of Hormuz Petrochemical personnel in Assalouye. In this experimental research, 60 male employees with at least one year of work experience were randomly divided two experimental groups of 30 people (including the personnel of Hormoz Asalouye Petrochemical Company as the group exposed to respiratory pollutants) and the control (personnel of the Social Security Department of Kazeroon as the group not exposed to pollutants). In order to investigate the effects of respiratory pollutants on changes in blood parameters, blood samples were taken from both groups.Also, to determine the general health of the employees, the standard questionnaire of the Goldberg general health scale was used. Data analysis was done using independent t-test statistical method. The results showed that the amount of white blood cells, platelets and average platelet volume in the exposed group showed a significant difference compared to the non-exposed group (P≤0.05), but the amount of red blood cells and hemoglobin did not differ significantly between the two groups(P>0.05).It was also observed that air pollution has negative effects on mental health and in the group exposed to respiratory pollutants, it led to an increase in physical symptoms, depression and anxiety (P≤0.05). In line with the results of this research, it can be concluded that exposure to air pollutants significantly causes changes in hematological parameters and increase in general health symptoms.
Animal physiology
Mehdi Basaki
Abstract
A review on hibernation was done by extensive search in main databases, using appropriate keywords and reading the newer and more cited articles from more reliable journals. This review investigated biochemical and molecular strategies of hibernating mammals to combat cold and lack of food and water. ...
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A review on hibernation was done by extensive search in main databases, using appropriate keywords and reading the newer and more cited articles from more reliable journals. This review investigated biochemical and molecular strategies of hibernating mammals to combat cold and lack of food and water. Growth and survival in times of resource scarcity require behavioral, physiological, cellular, and molecular adaptation in a relatively short time. Hibernation is a set of physiological strategies that allow animals to live in cold and lack food and water. Mammalian hibernation is a physiological state during which animals repeatedly experience periods of torpor and Interbout arousal. Hibernation varies in different kinds of animals. The inactive periods of heterotherms are more like deep sleep than hibernation. Voluntary hibernators enter a dormant period only when food resources are low, the weather is cold, and the season is changing. Obligate hibernations enter the inactive period seasonally, regardless of food availability, ambient temperature, and photoperiod. Obligate hibernating mammals can slow their metabolism, lower their body temperature, and fall into a torpor state. The energy supply is mainly made from fats stored pre-hibernation in this stage. This is associated with the upregulation of enzymes responsible for carbohydrate metabolism and the downregulation of enzymes responsible for fatty acid oxidation during hibernation. Non-stimulation of smell, taste, and oral-pharyngeal and digestive nerves and hormones such as leptin and insulin play a role in the neural suppression of feeding behavior from the hypothalamus. As water leaves the muscles, the plasma osmolality of hibernating animals decreases. Reducing blood osmolality acts as a thirst-suppression message to the brain. Hibernations are tolerant to cold both behaviorally and at the cellular level because the sensory neurons in these animals are less sensitive to cold. Also, hibernators have less cold-sensitive neurons in their hypothalamus. Hibernation is not simply a reduction in body temperature and vital parameters, but an active process that is seasonally regulated at the cellular and molecular levels. This seasonal adaptation is controlled by hormonal, neural, genetic, and epigenetic regulations. As different kinds of animals can hibernate, comparative studies are necessary to discover the central events of hibernation. What we have learned from the mechanism of animals hibernation can be used to develop methods to improve human health. Hibernation strategies can help reduce muscle and bone disuse atrophy, increase limb preservation time, fight obesity, and prevent reperfusion injury following myocardial infarction and stroke. Many questions about hibernation remain to be addressed in future research.
Animal physiology
Seyed Reza Pourrabie
Abstract
Alzheimer's disease is one of the most common neurodegenerative diseases. Beta-amyloid plaques and neurofibrillary tangles are two important factors in Alzheimer's disease. Many cellular changes, such as oxidative stress, neuronal inflammation, and mitochondrial disorders are also seen in Alzheimer's ...
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Alzheimer's disease is one of the most common neurodegenerative diseases. Beta-amyloid plaques and neurofibrillary tangles are two important factors in Alzheimer's disease. Many cellular changes, such as oxidative stress, neuronal inflammation, and mitochondrial disorders are also seen in Alzheimer's disease, which lead to neuronal death. Kaempferol, one of the plant flavonoids derived from the chamomile plant, has important effects on disorders related to brain diseases such as Alzheimer's disease due to the production of antioxidants.In this study, the effects of chamomile plant flavonoids on memory disorders in Alzheimer's rats were studied. For prepare and purify kaempferol, the hydroalcoholic extract of the collected chamomiles, and quantitative-qualitative analysis of the chemical substances of the chamomile extract using gas chromatograph connected to mass spectrometer (GC/MS) method were used. In this study, we used of 56 adult male rats were divided into 7 groups including control - vehicle 1 (kaempferol solvent) - vehicle 2 (streptozotocin drug solvent) - Alzheimer's - kaempferol 120mg/kg - kaempferol 250mg/kg - kaempferol 400mg/kg. Diabetes was induced by injecting a single dose of 60 mg/kg streptozotocin intraperitoneally. Kaempferol were administered for 15 days. The shuttle box device was used to measure memory and learning, and the delay time in the shuttle box was recorded. The results were analyzed by SPSS 22 software, ANOVA and Tokay tests. The significance of the data difference was considered at the p ≤ 0.05 levels. The results of the data analysis showed that the doses of 400 mg/kg and 250 mg/kg of kaempferol of chamomile plant significantly increased the delay time in entering the dark section at p≤0.001 compared to the control group and improved spatial memory in rats. Which does this effect is probably due to the presence of compounds such as quercetin and phytoestrogens. Also, oxidative stress parameters were significantly reduced in Alzheimer's groups treated with chamomile flavonoids (P < 0.001) . The results of the experiments show that plant flavonoids are able to restore the spatial memory and oxidative stress parameters of the groups treated with streptozotocin to normal levels.
Animal physiology
Nabiallah Salari; Yadollah Badakhshan; Rohallah Mirmahmoudi; Jamil Bahrampour; Arsalan Barazandeh
Abstract
Tryptophan is 3 th essential amino acid for the body. Also an important substrate for essential hormones such as serotonin and melatonin. This amino acid is metabolized in two ways in the body 1- Kynurunine pathway and 2- serotonin pathway. Tryptophan entry to These metabolizing pathways is five percent ...
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Tryptophan is 3 th essential amino acid for the body. Also an important substrate for essential hormones such as serotonin and melatonin. This amino acid is metabolized in two ways in the body 1- Kynurunine pathway and 2- serotonin pathway. Tryptophan entry to These metabolizing pathways is five percent for serotonin production and ninety and five percent for kynurenine production. This experiment was performed to evaluate the Effect of intraperitoneal injection of the L-tryptophan on feed intake, rectal temperature, and some blood biochemical metabolites of the Kermani sheep breed. 20 eight-month-old lambs grouped in 10 males and 10 females in a factorial design. Lambs were divided into control groups (saline intraperitoneal injection) and treatment groups (intraperitoneal injection with 50 mg tryptophan amino acid/kg body weight ). The Control group of each gender was injected only with physiological serum intraperitoneally .immediately after injection, the feed was offered to them and cumulative feed intake was measured in 2 hours intervals for a four-hour duration. Feed was a total mixed ration consisting of 40 % concentrated and 60 % roughage. Heartbeat, respiration rate, and rectal temperature were measured every hour after amino acid or saline injection. This experiment showed that feed intake in tryptophan treatment was reduced compared to the control group, also female lambs had significantly lower cumulative feed intake (P<0.05). Heart rate decreased in males and tryptophan treatment (P<0.05). Tryptophan injection significantly reduced rectal temperature (P<0.05). Tryptophan injection did not show a significant effect on the serum concentrations of T3 and T4 hormones of lambs (P>0.05) but reduced the ratio of T3 to T4 (P<0.05). this means thyroxin converted to triiodothyronine more effectively in the group that received tryptophan amino acid. Levels of cortisol, total protein, cholesterol, triglyceride, creatine, and urea were not significantly different in the tryptophan-receiving lamb compared to the control group (P>0.05). Serum albumin concentration decreased in tryptophan-receiving lambs compared to the control group (P<0.05).blood Albumin level was decreased in tryptophan-injected lamb compared with the control group (P<0.05). According to the results of this experiment, reduction of heart rate and rectal temperature in tryptophan treatment, it could be concluded that tryptophan improves the condition of livestock under heat stress by affecting the mechanisms of coping with high ambient temperature. These mechanisms are related to heartbeat and respiration rate control centers that were affected by intraperitoneal injection of tryptophan amino acid. Tryptophan in route of intraperitoneal injection significantly reduced cumulative feed intake but this was compensated for some hours of post-injection.
Animal physiology
Fatemeh Danesh Pajooh; Shahrbanoo Oryan; Ramesh Ahmadi; Pejman Mortazavi
Abstract
Liver fibrosis is a reversible disease that can be caused by various causes of liver damage and ultimately lead to severe complications such as cirrhosis, liver cancer or even death. Traditional treatments have several limitations, including insufficient therapeutic effects and side effects. Since the ...
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Liver fibrosis is a reversible disease that can be caused by various causes of liver damage and ultimately lead to severe complications such as cirrhosis, liver cancer or even death. Traditional treatments have several limitations, including insufficient therapeutic effects and side effects. Since the internalization, penetration and delivery of drugs have been facilitated with the help of nanomedicine, therefore, the use of nanotechnology in targeted drug delivery to improve liver fibrosis seems to be a suitable option. Male Wistar rats weighing 200-250 g were randomly divided into 5 groups of 8: control (healthy rats), sham (healthy rats + K3PO4), CCL4 (liver fibrosis model rats), Y2O3 30 (healthy rats + 30 mg/kg Y2O3) and CCL4+ Y2O3 30 (fibrotic rats + 30 mg/kg Y2O3). After induction of liver fibrosis by CCL4, rats received Y2O3 once daily for four weeks. At the end, the rats were anesthetized and blood was taken from the heart. A part of the liver samples was kept in 10% formalin and another part was kept at -80°C. Finally, oxidative stress markers (CAT, GPX, SOD and MDA) and liver enzyme levels (AST, ALT, ALP and GGT) were measured using ELISA method. Also, the expression of TGF-β and α-SMA genes in the liver was investigated by Real Time RT-PCR method. The use of 30 mg/kg of Y2O3 NPs did not have a favorable effect on regulating the levels of CAT, SOD, GPX, TGF-β and α-SMA, as well as MDA, AST, ALT, ALP and GGT in fibrotic rats. However, a significant improvement was observed in reducing liver tissue inflammation in CCL4+ Y2O3 30 group rats. The dose of 30 mg/kg of Y2O3 nanoparticles did not have a favorable effect on the antioxidant and biochemical indices of the liver in order to reduce liver fibrosis. But its favorable effects were observed in the fibrotic liver tissue of mice treated with Y2O3 30, especially the reduction of inflammation.
Animal physiology
Hamed Daneshpazhouh; Nasim Hayati Roodbari; Mehdi Dianatpour; Yaser Tahamtani; zahra khodabandeh
Abstract
Freezing is a long-term egg storage method that plays an important role in assisted reproductive methods. The aim of the present study is to investigate the effect of freezing solutions and docetaxel on the expression changes of autophagy genes such as Atg5 and Beclin-1 in mouse MII oocytes after glass ...
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Freezing is a long-term egg storage method that plays an important role in assisted reproductive methods. The aim of the present study is to investigate the effect of freezing solutions and docetaxel on the expression changes of autophagy genes such as Atg5 and Beclin-1 in mouse MII oocytes after glass freezing by cryotop method. To achieve this goal, mouse MII oocytes were collected and frozen in two different concentrations of 15% ethylene glycol, 15% dimethyl sulfoxide and 0.5 M sucrose in group A (VS1) and 7.5% ethylene glycol, glycerol. 7.5% and 0.5 M sucrose were frozen in group B (VS2) and some groups were affected by docetaxel before freezing. After thawing, the eggs were fertilized.The percentage of survival and fertilization of frozen and thawed oocytes was evaluated and the expression changes of genes (Atg5 and Beclin-1) were investigated by RT-PCR method. The results showed that there are significant differences between the percentage of survival and the percentage of fertilization in the freezing groups compared to the control group (P<0.05). The percentage of survival and fertilization in the VS1 group decreased compared to the VS2 group. Also, the percentage of survival and conception of the groups pre-incubated with Docetaxel was higher than the non-incubated groups. This study showed that vitrification with cryotop changes the transcript levels of autophagy genes in frozen-thawed MII oocytes, and pre-incubation of oocytes with docetaxel before vitrification can decrease the transcript levels of Atg5 and Beclin-1 in the experimental groups and above Increase the percentage of survival and the percentage of formation of two-celled embryos.
Animal physiology
Fatemeh Shahbazi
Abstract
The bilateral relationship between Ventro Medial Nucleus and dopaminergic system may play an important role in the secretion of the gastrointestinal exocrine glands, nutritional behaviors and habits. The aim of this study was to investigate the role of dopaminergic receptors in regulation of the exocrine ...
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The bilateral relationship between Ventro Medial Nucleus and dopaminergic system may play an important role in the secretion of the gastrointestinal exocrine glands, nutritional behaviors and habits. The aim of this study was to investigate the role of dopaminergic receptors in regulation of the exocrine glands and to find out whether the change in saliva secretion is the primary effects of central nervous system or there are subsequences of taking food, lick, swallowing and digestion in the mouth. Ninety rats were stereotaxically implanted under urethane anesthesia. The rats were divided into 9 groups: one control group, one fasted control group, two sham groups given surgery and surgery plus medicine solvents, one SCH23390 group, one bromocriptine group, one mixed group: SCH23390 along with bromocriptine, one pilocarpine and a mixed group: bromocriptine along with pilocarpine. In this study, saliva secretion was gathered from submandibular glands by cannulas and measures then volume of secretion by using SPSS program the groups were compared (Test Anova). The saliva secretion was not significantly different between all groups except SCH23390 group, pilocarpine, and both mixed groups which showed significant differences in the saliva secretion. This study showed that SCH23390 (7.5 μg) could increase saliva secretion. Bromocriptine could not affect saliva secretion. Bromocriptine along with pilocarpine significantly decreased saliva secretion. However, this agonist together with SCH23390 significantly increased saliva secretion. So the dopaminergic system of the Ventro Medial Nucleus has a considerable effect on the secretion of the exocrine glands in the digestive system.
Animal physiology
Fatemeh Shahbazi
Abstract
The goal of this study was to find out whether the change in saliva secretion is the primary effects of these agents or there are subsequences of taking food, lick, swallowing and digestion in the mouth. In this study, 70 rats were stereotaxically implanted under urethane anesthesia. The rats were divided ...
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The goal of this study was to find out whether the change in saliva secretion is the primary effects of these agents or there are subsequences of taking food, lick, swallowing and digestion in the mouth. In this study, 70 rats were stereotaxically implanted under urethane anesthesia. The rats were divided into 7 groups: one control group, two sham groups given medicine solvents, two sulpiride groups (4 μg and 8 μg), one bromocriptine group (25 μg) and a mixed group: sulpiride 8 μg along with bromocriptine 25 μg. In this study, saliva secretion was gathered from submandibular glands by cannulas and measures then volume of secretion by using SPSS program the groups were compared (Test Anova). The saliva secretion was not significantly different between all groups except sulpiride 8 μg group and a mixed group which showed significant differences in the saliva secretion. This study showed that sulpiride (8 μg) could increase saliva secretion, while sulpiride (4 μg) couldn’t increase saliva secretion. Bromocriptine (25 μg) could not affect saliva secretion. However, bromocriptine (25 μg) along with sulpiride 8 μg significantly increased saliva secretion. So the dopaminergic system of the VMN has a considerable effect on the secretion the exocrine glands in the digestive system.
Animal physiology
Fatemeh Shahbazi
Abstract
Injection of sulpiride (D2 receptor antagonist, antipsychotic drug) into VMN hypothalamus, increased gastric volume secretion and decreased gastric pH. The present study the effect of SCH23390 (D1 dopamine receptor antagonist) on the gastric acid secretion and its acidity were studied. 70 rats were divided ...
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Injection of sulpiride (D2 receptor antagonist, antipsychotic drug) into VMN hypothalamus, increased gastric volume secretion and decreased gastric pH. The present study the effect of SCH23390 (D1 dopamine receptor antagonist) on the gastric acid secretion and its acidity were studied. 70 rats were divided into 7 groups: two control groups, two sham groups given medicine solvents, a SCH23390 group (7.5µg), and bromocriptine group (25µg) and a mixed group: SCH23390 7.5µg along with bromocriptine 25µg. Gastric secretion volume was taken by syringe 2CC and by using SPSS program the groups were compared (Test Anova). Results showed that SCH23390 group (7.5µg) could increase volume of gastric secretion and decrease gastric acidity, while Bromocriptine (25µg) could not affect gastric volume secretion and its acidity. However, bromocriptine (25µg) along with SCH23390 7.5µg significantly increased gastric volume secretion and its acidity. There for the dopaminergic system of the VMN has a considerable effect on the secretion of the exocrine glands in the digestive system.
