Medical physiology
Sima Nasri; Mohammad Oraki; Nadereh Amin
Abstract
Aging is a natural process and increase of age in synchronized societies is associated with behavioral and physiological challenges. The most important of these challenges are the three indicators of perceived stress, depression and cortisol hormone. This research was conducted to compare levels of cortisol ...
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Aging is a natural process and increase of age in synchronized societies is associated with behavioral and physiological challenges. The most important of these challenges are the three indicators of perceived stress, depression and cortisol hormone. This research was conducted to compare levels of cortisol hormone with perceived stress and depression in elderly women living in private old people’s homes and private houses in Tehran. The statistical population included elderly women aged between 65 to 75 years old that were residents of the private old people’s homes and private houses in Tehran. Data were collected by the Beck Depression Inventory, Perceived Stress Scale developed by Sheldon Cohen, and determination of serum cortisol levels in the laboratory. The results of this study showed that levels of cortisol hormone and depression in elderly women living in the private old people’s homes and private houses had a significant difference (p <0.05). The perceived stress variable had no significant difference. The difference in depression rate may be due to family relationships and the presence of family members at the private houses, and non-existence of difference in the perceived stress rate and its inverse ratio with increase of age may be due to the experience and credibility of events in the world. Considering the impact of the living environment on the psychological problems in the elderly, national measures should be taken to improve the quality of life of the elderly and to empower them through social and governmental movements.
Zahra Nazari Parchestani; Maryam Rafieirad
Abstract
Ischemia in rat brain causes severe neuronal damage and consequently anxiety and depression disorders. The herniarin has a phenolic compound and is a powerful antioxidant. The aim of this study was to investigate the effect of herniarin on anxiety and depression in ischemia model in male rats. In this ...
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Ischemia in rat brain causes severe neuronal damage and consequently anxiety and depression disorders. The herniarin has a phenolic compound and is a powerful antioxidant. The aim of this study was to investigate the effect of herniarin on anxiety and depression in ischemia model in male rats. In this experimental study, 50 male Wistar rats(200-250g) were divided into 5 groups: control group, sham and ischemic group and ischemic groups receiving doses of 150 and 300 mg/kg herniarin by gavage method. To induce ischemia, bilateral carotid arteries were separated, blocked in two, and cut off in the middle section. Anxiety assessment was performed during the open-box test. Immobility time in forced swimming was also measured to measure depression. In the ischemic rats a significantly increased anxiety and an increase of mobility duration in both open box and forced swimming tests were observed (P<0.001). When the doses of 150-300 mg/kg herniarin was prescribed the times of elevation of hands was increased (P<0.001) and a significantly reduction of excretion times in each dose was observed (P<0.001) and consumption of herniarin doses 150-300 mg/kg was significantly increased in the ischemicrats when they passed several times through squares in the open box (P<0.001). herniarin has the effect of both anti-anxiety and- depression in the experimental model.
