Animal physiology
Seyed Reza Pourrabie
Abstract
Alzheimer's disease is one of the most common neurodegenerative diseases. Beta-amyloid plaques and neurofibrillary tangles are two important factors in Alzheimer's disease. Many cellular changes, such as oxidative stress, neuronal inflammation, and mitochondrial disorders are also seen in Alzheimer's ...
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Alzheimer's disease is one of the most common neurodegenerative diseases. Beta-amyloid plaques and neurofibrillary tangles are two important factors in Alzheimer's disease. Many cellular changes, such as oxidative stress, neuronal inflammation, and mitochondrial disorders are also seen in Alzheimer's disease, which lead to neuronal death. Kaempferol, one of the plant flavonoids derived from the chamomile plant, has important effects on disorders related to brain diseases such as Alzheimer's disease due to the production of antioxidants.In this study, the effects of chamomile plant flavonoids on memory disorders in Alzheimer's rats were studied. For prepare and purify kaempferol, the hydroalcoholic extract of the collected chamomiles, and quantitative-qualitative analysis of the chemical substances of the chamomile extract using gas chromatograph connected to mass spectrometer (GC/MS) method were used. In this study, we used of 56 adult male rats were divided into 7 groups including control - vehicle 1 (kaempferol solvent) - vehicle 2 (streptozotocin drug solvent) - Alzheimer's - kaempferol 120mg/kg - kaempferol 250mg/kg - kaempferol 400mg/kg. Diabetes was induced by injecting a single dose of 60 mg/kg streptozotocin intraperitoneally. Kaempferol were administered for 15 days. The shuttle box device was used to measure memory and learning, and the delay time in the shuttle box was recorded. The results were analyzed by SPSS 22 software, ANOVA and Tokay tests. The significance of the data difference was considered at the p ≤ 0.05 levels. The results of the data analysis showed that the doses of 400 mg/kg and 250 mg/kg of kaempferol of chamomile plant significantly increased the delay time in entering the dark section at p≤0.001 compared to the control group and improved spatial memory in rats. Which does this effect is probably due to the presence of compounds such as quercetin and phytoestrogens. Also, oxidative stress parameters were significantly reduced in Alzheimer's groups treated with chamomile flavonoids (P < 0.001) . The results of the experiments show that plant flavonoids are able to restore the spatial memory and oxidative stress parameters of the groups treated with streptozotocin to normal levels.
Seyed Reza Pourrabie
Abstract
Diabetes disrupts processes related to learning, memory, and cognition. Considering the potential anti-diabetic effect of the medicinal plant turmeric (curcumin) and its enhancing effect on memory and learning, in this research, the effect of inter peritoneal administration of the curcumin on learning ...
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Diabetes disrupts processes related to learning, memory, and cognition. Considering the potential anti-diabetic effect of the medicinal plant turmeric (curcumin) and its enhancing effect on memory and learning, in this research, the effect of inter peritoneal administration of the curcumin on learning and memory in diabetic rats was investigated. In this study, the male rats were divided into five groups: control, control treated with curcumin 50 mg / kg, diabetic and diabetic treated with curcumin 10 and 50 mg/kg. Curcumin was administered for five weeks after seven days of streptozotocin 60mg/kg interparietal injection and the passive avoidance task was assessed through the operation. Streptozotocin injection significantly increased blood glucose and markedly decreased both STL1 (the short memory) and STL2 (the long memory) in the avoidance learning test. Chronic administration of curcumin as an active ingredient in turmeric significantly increased short-term and long-term memory in the diabetic groups. Therefore, chronic use of cinacurcumin reduced memory and learning impairment and enhanced the capability of memory and recall in diabetic rats.
