Seyed Reza Pourrabie
Abstract
Diabetes disrupts processes related to learning, memory, and cognition. Considering the potential anti-diabetic effect of the medicinal plant turmeric (curcumin) and its enhancing effect on memory and learning, in this research, the effect of inter peritoneal administration of the curcumin on learning ...
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Diabetes disrupts processes related to learning, memory, and cognition. Considering the potential anti-diabetic effect of the medicinal plant turmeric (curcumin) and its enhancing effect on memory and learning, in this research, the effect of inter peritoneal administration of the curcumin on learning and memory in diabetic rats was investigated. In this study, the male rats were divided into five groups: control, control treated with curcumin 50 mg / kg, diabetic and diabetic treated with curcumin 10 and 50 mg/kg. Curcumin was administered for five weeks after seven days of streptozotocin 60mg/kg interparietal injection and the passive avoidance task was assessed through the operation. Streptozotocin injection significantly increased blood glucose and markedly decreased both STL1 (the short memory) and STL2 (the long memory) in the avoidance learning test. Chronic administration of curcumin as an active ingredient in turmeric significantly increased short-term and long-term memory in the diabetic groups. Therefore, chronic use of cinacurcumin reduced memory and learning impairment and enhanced the capability of memory and recall in diabetic rats.
