Animal physiology
Habibe Zare; Naeimeh Dehghani; Hamed Daneshpazhouh
Abstract
Natural resources such as plants are a safe therapeutic option in treating cancers and reducing the side effects of current treatments. Sage is an aromatic and medicinal plant known for its antioxidant properties. It has been used as an antispasmodic, astringent, sedative, anti-hyperglycemic, and anti-inflammatory ...
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Natural resources such as plants are a safe therapeutic option in treating cancers and reducing the side effects of current treatments. Sage is an aromatic and medicinal plant known for its antioxidant properties. It has been used as an antispasmodic, astringent, sedative, anti-hyperglycemic, and anti-inflammatory agent in Iranian medicine. In the present study, the anticancer effects of compounds found in sage extracts, such as cineole and camphor, were studied. For this purpose, cancer was first induced in mice by (dimethylbenzanthracene) dissolved in sunflower oil for 4 weeks. Then, different tumor cell lines were exposed to the extracts. For this purpose, the experimental group was treated with a hydroalcoholic extract of sage leaves for 4 weeks. While the control group received distilled water. Then, tissue sections were taken from the samples and the groups were statistically compared with each other. The findings indicate the therapeutic effects of sage. Sage can potentially prevent breast cancer.
Zahra Nazari Parchestani; Maryam Rafieirad
Abstract
Ischemia in rat brain causes severe neuronal damage and consequently anxiety and depression disorders. The herniarin has a phenolic compound and is a powerful antioxidant. The aim of this study was to investigate the effect of herniarin on anxiety and depression in ischemia model in male rats. In this ...
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Ischemia in rat brain causes severe neuronal damage and consequently anxiety and depression disorders. The herniarin has a phenolic compound and is a powerful antioxidant. The aim of this study was to investigate the effect of herniarin on anxiety and depression in ischemia model in male rats. In this experimental study, 50 male Wistar rats(200-250g) were divided into 5 groups: control group, sham and ischemic group and ischemic groups receiving doses of 150 and 300 mg/kg herniarin by gavage method. To induce ischemia, bilateral carotid arteries were separated, blocked in two, and cut off in the middle section. Anxiety assessment was performed during the open-box test. Immobility time in forced swimming was also measured to measure depression. In the ischemic rats a significantly increased anxiety and an increase of mobility duration in both open box and forced swimming tests were observed (P<0.001). When the doses of 150-300 mg/kg herniarin was prescribed the times of elevation of hands was increased (P<0.001) and a significantly reduction of excretion times in each dose was observed (P<0.001) and consumption of herniarin doses 150-300 mg/kg was significantly increased in the ischemicrats when they passed several times through squares in the open box (P<0.001). herniarin has the effect of both anti-anxiety and- depression in the experimental model.
