Seyed Reza Pourrabie
Abstract
Diabetes disrupts processes related to learning, memory, and cognition. Considering the potential anti-diabetic effect of the medicinal plant turmeric (curcumin) and its enhancing effect on memory and learning, in this research, the effect of inter peritoneal administration of the curcumin on learning ...
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Diabetes disrupts processes related to learning, memory, and cognition. Considering the potential anti-diabetic effect of the medicinal plant turmeric (curcumin) and its enhancing effect on memory and learning, in this research, the effect of inter peritoneal administration of the curcumin on learning and memory in diabetic rats was investigated. In this study, the male rats were divided into five groups: control, control treated with curcumin 50 mg / kg, diabetic and diabetic treated with curcumin 10 and 50 mg/kg. Curcumin was administered for five weeks after seven days of streptozotocin 60mg/kg interparietal injection and the passive avoidance task was assessed through the operation. Streptozotocin injection significantly increased blood glucose and markedly decreased both STL1 (the short memory) and STL2 (the long memory) in the avoidance learning test. Chronic administration of curcumin as an active ingredient in turmeric significantly increased short-term and long-term memory in the diabetic groups. Therefore, chronic use of cinacurcumin reduced memory and learning impairment and enhanced the capability of memory and recall in diabetic rats.
Seyed Reza Pourrabie; Alireza Mohajjel Naebi
Abstract
Alzheimer's disease is a common form of progressive dementia and usually occurs between the sixth and ninth decades of life, given that there is a direct relationship between steroid hormones and neurodegenerative diseases, so the present study was designed to explore effect of testosterone in memory ...
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Alzheimer's disease is a common form of progressive dementia and usually occurs between the sixth and ninth decades of life, given that there is a direct relationship between steroid hormones and neurodegenerative diseases, so the present study was designed to explore effect of testosterone in memory impairment induced by intra-cerebroventricular (icv) injection of streptozptocin (STZ) as a model of sporadic Alzheimer disease (AD). Study was carried out on male Wistar rats. Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (3mg/kg/icv) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg/kg.d, SC), the androgen receptor antagonist flutamide (10 mg/kg.d, ip), the estrogen receptor antagonist tamoxifen (1 mg/kg.d, ip) or the aromatase inhibitor letrozole (4 mg/kg.d, ip) were administered for 6 d after the first injection of STZ. STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats.
