pharmacology
Sayeh Bidaran; Sima Nasri
Articles in Press, Accepted Manuscript, Available Online from 02 December 2013
Abstract
Introduction & Objective: Zinc is an essential element for the immune system. This element has different effects on immune system activity. On the other hand different serum Zn levels also alter normal B-cell line and T-cell line functions. The present study was carried out to assess B cell line and ...
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Introduction & Objective: Zinc is an essential element for the immune system. This element has different effects on immune system activity. On the other hand different serum Zn levels also alter normal B-cell line and T-cell line functions. The present study was carried out to assess B cell line and T cell line tolerance to low concentration Zinc Chloride In vitro studyMaterials & Methods: This experimental study was conducted at the Payame Noor University of Tehran in 2010. The B- cell line and T-cell line were exposed to 1, 5, 10, 20, 30, 40, 50, 75, 100,125, 150,175 and 200 µm (λ) of Zinc Chloride followed by incubation at 12, 24, 36, 48, 60 and 72 hrs. Viability of B- cell line (Raji) and T-cell line (molt-4) were evaluated with hemocytometer method and percentage of living cells have been considered as cellular tolerance index to cytotoxic effects of Zinc chloride. The results were analyzed by SPSS software, version 18 using T-test and Kruskal-Wallis testResults: In this study, the results showed Zinc chloride concentrations up to 40 µm (λ) at different incubation time points (12-72 hrs) had no effects on B cell line and T cell line viability( p> 0.05) With 50-200 µm (λ) concentrations, Zinc at different incubation time points(12-72 hrs)
Pooran Ghahramani; Hooman Eshagh Harooni; Seyed Raza Fatemi Tabatabaei; Ahmad Ali Moazedi
Abstract
Abstract Anxiety is a common disease in the society. About 500 million people worldwide suffer from this disorder. 85% of people with depression also have anxiety. According to anxiolytic effects of different zinc chloride in male and female rats is Castration post- pubertaly, this was investigated, ...
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Abstract Anxiety is a common disease in the society. About 500 million people worldwide suffer from this disorder. 85% of people with depression also have anxiety. According to anxiolytic effects of different zinc chloride in male and female rats is Castration post- pubertaly, this was investigated, the effect of zinc chloride on anxiety and deppresive behaviors of rats, in gonadectomized peri-pubertaly. In this experiment, fifty male rats were gonadectomized at postnatal day 21-22 and at puberty were divided into Six groups, control, sham (saline), gonadectomized (saline) and the gonadectomized groups receiving Zinc chloride 5, 10 and 20 mg/kg. Then on postnatal day 75, different doses of zinc chloride (5, 10 and 20 mg/kg; IP) were administered 30 min before the elevated plus maze and forced swimming test. The results showed in gonadectomized group (saline) anxiety did not reach to a significant criterion. Zinc chloride (20 mg/kg) significantly increase the time spent in the open arms in gonadectomized (20 mg/kg) group compared to the gonadectomized group (p
Parvin Sadeghi; Naghimeh Kesalkhe
Volume 6, Issue 2 , December 2017, , Pages 27-34
Abstract
The aim of the present study was investigated the evaluation of the Median Lethal Concentration (LC50) Toxicity of Zinc Chloride (ZnCl2) and its effect on behavioral responses of gray mullet (Mugil cephalus). For this experiment, healthy of gray mullet with mean weight 7.42 g and mean length 6.51cm were ...
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The aim of the present study was investigated the evaluation of the Median Lethal Concentration (LC50) Toxicity of Zinc Chloride (ZnCl2) and its effect on behavioral responses of gray mullet (Mugil cephalus). For this experiment, healthy of gray mullet with mean weight 7.42 g and mean length 6.51cm were captured from the Chabahar Bay. At the first, fish were exposed to ZnCl2 at several selected concentrations 0.25, 0.5, 1, 5, 10, 15, 20, 30, 40 ppm for rang finding test, then fish exposed to four concentrations 16, 17, 18 1nd 19 mg/L of Zncl2 for LC50-96h. Experiment was carried out in triplicate and 21 fish per each treatment. Physicochemical properties of water were measured continuously throughout the experiment. The temperature, pH, dissolved oxygen and salinity were 30 ◦C, 7.75, 8.25 mgO2 L-1 and 38 ppt respectively. Number of mortality and behavioral responses of fish were recorded after 24, 48, 72 and 96 h. The behavioral changes observed in fish at the experiment period included reversal, swimming on water surface, nervous manifestations, swallowing air, rapid opening and closing of the operculum, congestion and bleeding of mouth, gills and fish fins and slow down motility change of body coloration and increased of mucus secretion. LC50 of zinc chloride value was calculated with spss and probit analysis and was determined to be 17.33 mg/L in a static bioassay test system.
Edris Rahimikia; Sara Vali; Paria Akbary; Abdolreza Jahanbakhshi
Volume 5, Issue 1 , September 2016, , Pages 23-29
Abstract
Heavy metals are the important pollution which there is in the aquatic ecosystems. Today, with advances in technology have increased the pollution therefore it is important to assessment the risks. The aim of this study was acute toxicity effects of mercury chloride, lead chloride and zinc chloride ...
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Heavy metals are the important pollution which there is in the aquatic ecosystems. Today, with advances in technology have increased the pollution therefore it is important to assessment the risks. The aim of this study was acute toxicity effects of mercury chloride, lead chloride and zinc chloride in silver carp fish. In this study there were 5 treatments for lead chloride and mercury chloride and 6 treatments for zinc chloride. The average lethal concentration (LC50) of these insecticides on fish within 96 hours was determined using probit analysis. Toxicity tests at 96 hours, 100% mortality shown at 1 mg per liter concentration for mercuric chloride and 60 mg per liter concentration for lead chloride and zinc chloride. LC50 96h was for mercuric chloride 0.55±0.63, Lead chloride 39.9±0.76 and Zinc chloride on 41.1±0.20. Based on this it was concluded that mercury chloride more toxic to silver carp fish compare to lead and zinc chloride so we should prevent the entrance of such substances, specific mercury, to the aquatic ecosystems.
S. Nasri; sayeh. bidaran; P. Nasiri
Volume 1, Issue 2 , November 2012, , Pages 33-42
Abstract
Introduction & Objective: Zinc is an essential element for the immune system. This element has different effects on immune system activity. On the other hand, different serum Zn levels also alter normal B-cell line and T-cell line functions. The present study was carried out to assess B cell line ...
Read More
Introduction & Objective: Zinc is an essential element for the immune system. This element has different effects on immune system activity. On the other hand, different serum Zn levels also alter normal B-cell line and T-cell line functions. The present study was carried out to assess B cell line and T cell line tolerance to low concentration Zinc Chloride In vitro study. This experimental study was conducted at the Payame Noor University of Tehran in 2010. The B- cell line and T-cell line were exposed to 1, 5, 10, 20, 30, 40, 50, 75, 100,125, 150,175 and 200 µm (λ) of Zinc Chloride followed by incubation at 12, 24, 36, 48, 60 and 72 hrs. Viability of B- cell line (Raji) and T-cell line (molt-4) were evaluated with hemocytometer method and percentage of living cells have been considered as cellular tolerance index to cytotoxic effects of Zinc chloride. The results were analyzed by SPSS software, version 18 using T-test and Kruskal-Wallis test. In this study, the results showed Zinc chloride concentrations up to 40 µm (λ) at different incubation time points (12-72 hrs) had no effects on B cell line and T cell line viability ( p> 0.05) With 50-200 µm (λ) concentrations, Zinc at different incubation time points (12-72 hrs) tolerance B cell and T cell line decreased and viability decreased significantly when compared with the control group and test groups up to 40 µm (λ) concentration ( p< 0.05). All groups at different after incubation time , Zinc concentrations (50-200 µm ) B cell and T cell line tolerance decreased significantly when compared with Zinc chloride concentrations up to 40 µm (λ) ( p< 0.05). Zinc is necessary for the normal function of the immune system. A variety of in vitro effects of zinc on B cell line and T cell line depend on the zinc concentration. High dosages of zinc evoke negative effects on B cell line and T cell line. An excess of zinc can inhibit B- cell line and T-cell line function.
