histology
Naeimeh Dehghani
Abstract
Oxymetholone is a 17-alpha- alkamine and a synthetic derivative of testosterone, which is obtained through the methylation of the 17-alpha carbon and the saturation of the 5-alpha carbon of testosterone. Oxymetholone is an anabolic-androgenic steroid which is used for the treatment of anemia caused ...
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Oxymetholone is a 17-alpha- alkamine and a synthetic derivative of testosterone, which is obtained through the methylation of the 17-alpha carbon and the saturation of the 5-alpha carbon of testosterone. Oxymetholone is an anabolic-androgenic steroid which is used for the treatment of anemia caused by severe bone marrow weakness and the prevention of the consequences of hereditary angioedema or the treatment of growth delay which of course is used in bodybuilding to increase muscle volume and strength. Considering the harmful effects on this drug on the body, we decided to determine the effects of oxymetholone on the oogenesis of NMRI mice. For this, was injected(12mg/kg/day) interaperitoneally to mice in 6 and 4 weeks age in one periods of 35 days. The results showed that the significant difference between treatment and control groups was observed( P<0.05). This teratogenic effects involved: decrese in ovarian weight, decrese in ovarian diameter, decrese in number of Corpuse luteum, increase of primordial follicles, decrese of primary follicles, decrese of growing follicles, decrese of graaf follicles, decrese in number of atretic follicle, decrese of granolosa layer diameter and decrese in progestron. Additionally in some experimental case, the disorder in formation of granolosa layers and don’t formation of corna radiate layers, disordering of ovule medulla and formation of two oocyte in one follicle were observed. The results showed that the use of this drug in the experimental group will have a negative effect on ovarian growth and ovulation.
Kazem Parivar; Nasim Hayati Roodbari; Alireza Badiei; Roghiyeh Taghizadeh Hajiagha
Volume 4, Issue 1 , September 2015, , Pages 1-10
Abstract
Abstract Increase in the use of nano zinc oxide in medicine, manufacturing cosmetic products and research, have raised the questions about their toxicity. Zinc has direct role in growth, maturation and ovulation through influence on production of estradiol and progesterone. In this study the effects ...
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Abstract Increase in the use of nano zinc oxide in medicine, manufacturing cosmetic products and research, have raised the questions about their toxicity. Zinc has direct role in growth, maturation and ovulation through influence on production of estradiol and progesterone. In this study the effects of nano zinc oxide on oogenesis of adult NMRI mouse strain have been investigated. The adult female mice were randomly divided into six groups, including control, sham and four experimental groups. Experimental groups were injected nano-ZnO (50-100-150-300 mg/kgbw) Intraperito-neally, respectively for 3 days. After 7 day, histological changes of ovaries were studied. Data indicated increase of numbers of Graafian follicles and corpora lutea in 100 and 150 mg/kg bw doses. Increase in estradiol and progestron levels with increase on dose was observed. Data indicated increase of numbers of atretic follicles with decreased body weight in higher doses. Results indicated oogenesis under 100 and 150 doses nano-Zno has improved with enhancing the number of Graafian follicles and corpora lutea, and decrease of body weight and increase of number of atretic follicles under higher doses. The results also indicated that nano-Zno has toxic effects on reproductive organs in female animal.
