Animal physiology
Fatemeh Shahbazi
Abstract
The bilateral relationship between Ventro Medial Nucleus and dopaminergic system may play an important role in the secretion of the gastrointestinal exocrine glands, nutritional behaviors and habits. The aim of this study was to investigate the role of dopaminergic receptors in regulation of the exocrine ...
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The bilateral relationship between Ventro Medial Nucleus and dopaminergic system may play an important role in the secretion of the gastrointestinal exocrine glands, nutritional behaviors and habits. The aim of this study was to investigate the role of dopaminergic receptors in regulation of the exocrine glands and to find out whether the change in saliva secretion is the primary effects of central nervous system or there are subsequences of taking food, lick, swallowing and digestion in the mouth. Ninety rats were stereotaxically implanted under urethane anesthesia. The rats were divided into 9 groups: one control group, one fasted control group, two sham groups given surgery and surgery plus medicine solvents, one SCH23390 group, one bromocriptine group, one mixed group: SCH23390 along with bromocriptine, one pilocarpine and a mixed group: bromocriptine along with pilocarpine. In this study, saliva secretion was gathered from submandibular glands by cannulas and measures then volume of secretion by using SPSS program the groups were compared (Test Anova). The saliva secretion was not significantly different between all groups except SCH23390 group, pilocarpine, and both mixed groups which showed significant differences in the saliva secretion. This study showed that SCH23390 (7.5 μg) could increase saliva secretion. Bromocriptine could not affect saliva secretion. Bromocriptine along with pilocarpine significantly decreased saliva secretion. However, this agonist together with SCH23390 significantly increased saliva secretion. So the dopaminergic system of the Ventro Medial Nucleus has a considerable effect on the secretion of the exocrine glands in the digestive system.
Animal physiology
Fatemeh Shahbazi
Abstract
Injection of sulpiride (D2 receptor antagonist, antipsychotic drug) into VMN hypothalamus, increased gastric volume secretion and decreased gastric pH. The present study the effect of SCH23390 (D1 dopamine receptor antagonist) on the gastric acid secretion and its acidity were studied. 70 rats were divided ...
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Injection of sulpiride (D2 receptor antagonist, antipsychotic drug) into VMN hypothalamus, increased gastric volume secretion and decreased gastric pH. The present study the effect of SCH23390 (D1 dopamine receptor antagonist) on the gastric acid secretion and its acidity were studied. 70 rats were divided into 7 groups: two control groups, two sham groups given medicine solvents, a SCH23390 group (7.5µg), and bromocriptine group (25µg) and a mixed group: SCH23390 7.5µg along with bromocriptine 25µg. Gastric secretion volume was taken by syringe 2CC and by using SPSS program the groups were compared (Test Anova). Results showed that SCH23390 group (7.5µg) could increase volume of gastric secretion and decrease gastric acidity, while Bromocriptine (25µg) could not affect gastric volume secretion and its acidity. However, bromocriptine (25µg) along with SCH23390 7.5µg significantly increased gastric volume secretion and its acidity. There for the dopaminergic system of the VMN has a considerable effect on the secretion of the exocrine glands in the digestive system.
