N Hayati Roodbari; K parivar; S Rezaee; A.R. Badiee
Volume 3, Issue 1 , January 2015, , Pages 27-38
Abstract
According to increasing use of nano materials and our daily exposure to them, it is required to investigate their effects on genital organs. Upon this purpose, in this resserch the effect of nano titanium dioxide on the spermatogenesis were studied. The effect of titanium dioxide with particle ...
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According to increasing use of nano materials and our daily exposure to them, it is required to investigate their effects on genital organs. Upon this purpose, in this resserch the effect of nano titanium dioxide on the spermatogenesis were studied. The effect of titanium dioxide with particle size of 10 nm on spermatogenesis of adult male NMRI mice strain in “in vivo” conditions was studied. Three groups: control (no treatment), sham (treated with distilled water), experimental (treatment with doses of 6, 30, 150, 300 mg / kg of nano titanium dioxide 10nm) were investigated. Intraperitoneal injection was applied for 5 consecutive days. 2 weeks after the last injection, mice were anesthetized and their testes and epididymis were removed. After fixing and preparing slides, they were examined. In this study, mouse weight, number of tubes in the testes and epididymis, tunica albuginea thickness, number of Leydig cells, fibroblasts, Sertoli and sperm numbers at three significant levels (p
