Biochemistry
Zhila Zareie; Alieh Eslampanah; shahriar saeidian
Abstract
The aim of the research is to determine the adequacy of dialysis in patients undergoing hemodialysis through the evaluation of serum Bun and Cr, before and after dialysis and investigate the biochemical effect of dialysis on kidney in Lar city. This research was descriptive-analytical and cross-sectional ...
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The aim of the research is to determine the adequacy of dialysis in patients undergoing hemodialysis through the evaluation of serum Bun and Cr, before and after dialysis and investigate the biochemical effect of dialysis on kidney in Lar city. This research was descriptive-analytical and cross-sectional on 135 patients undergoing dialysis. Data collection was done through the researcher's demographic questionnaire. Blood creatinine and urea levels were measured by Jaffe and enzymatic methods, respectively. Dialysis adequacy was calculated through KT/V and URR parameters. The data was analyzed using descriptive and inferential statistical tests in SPSS software and by Pair t-test. Most hemodialysis patients of these centers had KT/V less than 1.2. Also, 36.1% of the subjects had URR>65 and 47.5% had KT/V>1.2. A significant decrease in serum urea and creatinine after dialysis was observed. The comparison of the types of membranes in the amount of urea and creatinine clearance showed a difference between these membranes in correcting the amount of urea and creatinine, So, HD type was the most efficient and the R4 type was the least efficient. The S3 membrane has a higher filtration rate than others, which can be the reason for this difference. The average difference of alkaline phosphatase activity before and after dialysis with S3 membrane was more than other membranes, although this difference was not significant. BUN and creatinine showed a significant decrease after hemodialysis compared to before hemodialysis. The result showed that 36.1% had adequate dialysis; But in others, do not have adequate dialysis efficiency.
