Mansour Farajollahi Moghadam; Omolbanin Ghasemian
Abstract
Diabetes mellitus is one of the most serious global health problems, and its occurrence increases with age. Considering the relationship between aging and metabolic disorders, it seems that each year a large number of elderly people die due to cardiovascular diseases caused by these factors. The present ...
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Diabetes mellitus is one of the most serious global health problems, and its occurrence increases with age. Considering the relationship between aging and metabolic disorders, it seems that each year a large number of elderly people die due to cardiovascular diseases caused by these factors. The present study aimed to investigate the effect of four weeks of intense interval training along with the consumption of tryptophan supplementation on cardiac damage index in elderly diabetic rats. In this experimental study, 40 diabetic elderly rats were randomly divided into four groups, each group having 10 rats. These were control, sham, high-intensity interval training (HIIT), and HIIT+tryptophan supplementation (at a dose of 50 mg/kg) groups. The levels of lactate dehydrogenase (LDH), aspartate transaminase (AST), and creatine kinase-MB (CK-MB) was measured in each group. The results showed that the levels of LDH, AST, and CK-MB in the diabetic control group were significantly higher compared to the healthy control group (P= 0.05). Moreover, the LDH level in the HIIT + tryptophan group was significantly lower than that in the diabetic control group (P= 0.03). AST levels in the tryptophan, HIIT (P=0.001), and HIIT+tryptophan groups (P=0.001) were significantly lower compared to the diabetic control group (P= 0.001). Based on the obtained results, the indicators of heart disease improved with exercise and consumption of tryptophan. However, further studies are recommended to investigate the effects of intensity and type of training as well as the dosage of tryptophan in this regard.
