Articles in Press, Accepted Manuscript, Available Online from 20 November 2013
Abstract
Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin ...
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Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin (STZ) as a model of sporadic AD. In this research animals were divided randomly into 11 equal groups. Experimental model of AD was induced by bilateral icv injection of STZ. STZ-induced memory impairment was assessed two weeks after the last dose of STZ by using a passive avoidance task. The interval between the placement of animals in the illuminated chamber and the entry into the dark chamber was measured as step-through latency (STL). Castration was performed by surgical removing of testis and behavioral study of memory impairment was done after 4 weeks. Results of this study showed that icv injection of STZ could induce marked (p<0.001) memory impairment. Memory was worsened in castrated rats (P<0.001) when compared with normal and sham-operated animals. Testosterone replacement therapy in 4 week castrated rats restored memory up to the level of control groups. Testosterone had not any significant effect on memory impairments of non-castrated rats. According to the obtained results it can be concluded that testosterone improves cognitive and memory impairment of AD.
tahereh Nikkhah; Amir Arasteh
Abstract
Diabetes and liver diseases are serious problems and threaten the health of communities. Nettle has been introduced in traditional Iranian medicine as a blood glucose lowering drug. There are conflicting scientific reports about the effects of reducing the blood sugar of nettle, but this plant has good ...
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Diabetes and liver diseases are serious problems and threaten the health of communities. Nettle has been introduced in traditional Iranian medicine as a blood glucose lowering drug. There are conflicting scientific reports about the effects of reducing the blood sugar of nettle, but this plant has good antioxidant and anti-inflammatory properties to reduce liver damage. Current study, examines the anti-diabetic and liver protective effects of the aqueous extract of urtica dioica in vistar male rats. The mice were divided into five groups and in order to investigation of anti-diabetic and liver protective effects, test groups obtained daily 2.5 and 5 ml/kg of the aqueous extract of urtica dioica orally for 14 and 32 days, respectively. Blood glucose was measured with a glucometer and liver enzyme activity was measured with ParsAzmoon kits. The results were analyzed using Student's T–Test and ANOVA using SPSS software version 21. Blood sugar levels in first and second test groups (170 and 122 mg/dl) showed a significant decrease compared to the negative control group (446 mg/dl). The activity of liver enzymes in the first and second test groups also showed a significant decrease compared to the negative control group. The aqueous extract of urtica dioica has beneficial effects in managing diabetes and maintaining the health of liver cells against toxic compounds.
Yadolah Edalatpanah; Saied Rezaei Zarchi; Fariba Enayati Parvar; Susan Rostam Pour; Leila Moradi Jafari
Abstract
Abstract Diabetes mellitus is a common metabolic disorder, with complications caused by many health problems in society. Reducing blood glucose levels in diabetic patients with medicinal herbs is of great clinical importance. This study was performed to investigate the effects of Cedar Butanlite Extract ...
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Abstract Diabetes mellitus is a common metabolic disorder, with complications caused by many health problems in society. Reducing blood glucose levels in diabetic patients with medicinal herbs is of great clinical importance. This study was performed to investigate the effects of Cedar Butanlite Extract on insulin-induced hypoglycemia in Streptozotocin Wistar male diabetic rats. In this study, 40 Wistar rats with a weight range of 250-300 gr were selected and divided into 5 groups. Blood glucose levels were measured by glucose oxidase assay. Data were analyzed by SPSS-24 software and t-test. Charts were prepared using Excel software. The results showed that the mean glucose level of diabetic rats treated with insulin and alcoholic extract of cedar showed a significant decrease compared to insulin treatment and cedar treatment (P
Namdar Yousofvand; Vahid Hasanvand
Volume 7, Issue 1 , September 2018, , Pages 27-33
Abstract
Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and ...
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Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and food for 45 days and injected normal saline on 15th day. Control (diabetic by STZ at 40 mg/kg dose on 15th day) and the prevention group by garlic flower extract at a dose of 360 mg/Lit in drinking water received a treatment period for 15 days before diabetes. One dose of STZ 40mg/kg was injected intraperitoneally. The hematocrit of blood samples was measured, using the ABACUS-c Diatron device (Austria). Hematocrit showed a significant increase (p
Vahid Hasanvand; Namdar Yousofvand
Volume 6, Issue 4 , June 2018, , Pages 67-73
Abstract
Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water ...
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Abstract Many of the medicinal herbs have shown to be effective in reducing the incidence of diabetes complications (including hematocrit), which garlic is one of these herbs. 21 adult Wistar male rats were divided into 3 groups (n=7), which include: normal control group that received normal water and food for 45 days and injected normal saline on 15th day. Control (diabetic by STZ at 40 mg/kg dose on 15th day) and the prevention group by garlic flower extract at a dose of 360 mg/Lit in drinking water received a treatment period for 15 days before diabetes. One dose of streptozotocin 40mg/kg was injected intraperitoneally. The hematocrit of blood samples was measured, using the ABACUS-c Diatron device (Austria). Hematocrit showed a significant increase (p
Fatemeh Nabiyouni; Gholamhasan Vaezi; Ali Akbar Malekirad; Mohammad Abdollahi
Volume 5, Issue 1 , September 2016, , Pages 31-38
Abstract
Diabetes is one of the most common metabolic diseases and in the long term affects many parts of body, including liver and kidneys. This study was to investigate alcoholic extract effect of Alhagi camelorum on functional tests of liver and kidney in diabetic rats induced by streptozotocin. In this study, ...
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Diabetes is one of the most common metabolic diseases and in the long term affects many parts of body, including liver and kidneys. This study was to investigate alcoholic extract effect of Alhagi camelorum on functional tests of liver and kidney in diabetic rats induced by streptozotocin. In this study, 28 Wistar male rats were divided into the four groups (n = 7): non-diabetic control group received normal diet, diabetic group was induced by streptozotocin and received 1ml of normal saline daily as extract solvent , two diabetic experimental groups received alcoholic extract of Alhagi Camelorum at dose of 200 mg/kg and 300 mg/kg by gavage, respectively. To induce diabetes, streptozotocin was injected to rats intraperitoneally at dose of 50 mg/kg. Blood samples were collected at day 21 from all groups and the related blood factors were measured and analyzed by SPSS (ANOVA). The findings show that there was a significant increase in creatinine, urea levels and liver enzymes in diabetic control group when compared to the non-diabetic control group. While the same amount factors show decrease in the groups receiving alcoholic extract of Alhagi Camerolum. The results show that alcoholic extract of aerial parts of Alhagi Camerolum causes to the decreased creatinine, urea levels and liver enzymes.
S. R. Pourrabi1; A. R. Mohajjel Nayebi; S. E. Hossini
Volume 1, Issue 2 , November 2012, , Pages 25-32
Abstract
Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin ...
Read More
Steroidal sex hormones especially testosterone have a protective effect in neurodegenerative events such as Alzheimer Disease. The present study was designed to explore effect of testosterone and androgen receptors in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin (STZ) as a model of sporadic AD. In this research animals were divided randomly into 11 equal groups. Experimental model of AD was induced by bilateral icv injection of STZ. STZ-induced memory impairment was assessed two weeks after the last dose of STZ by using a passive avoidance task. The interval between the placement of animals in the illuminated chamber and the entry into the dark chamber was measured as step-through latency (STL). Castration was performed by surgical removing of testis and behavioral study of memory impairment was done after 4 weeks. Results of this study showed that icv injection of STZ could induce marked (p<0.001) memory impairment. Memory was worsened in castrated rats (P<0.001) when compared with normal and sham-operated animals. Testosterone replacement therapy in 4 week castrated rats restored memory up to the level of control groups. Testosterone had not any significant effect on memory impairments of non-castrated rats. According to the obtained results it can be concluded that testosterone improves cognitive and memory impairment of AD.
